Evidence map›Paper›PMID 28737775›Full record

ArticleBone marrow transplantation2017

Fertility preservation issues in pediatric hematopoietic stem cell transplantation: practical approaches from the consensus of the Pediatric Diseases Working Party of the EBMT and the International BFM Study Group.

A Balduzzi, J-H Dalle, K Jahnukainen, M von Wolff, G Lucchini, M Ifversen, K T Macklon, C Poirot, T Diesch, A Jarisch and 24 more

Open access · bronzeAbstract readConsensus Statement
PubMed Publisher
In one paragraph

Article in Bone marrow transplantation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 4 pooled it
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 64 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Article
  7. Review
  8. Hematopoietic Stem Cell Transplantation in Sickle Cell Disease.Advances in experimental medicine and biology · 2025
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Observational
  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors at 20 institutions in 14 countries.

A BalduzziClinica Pediatrica, Università degli Studi di Milano Bicocca, Fondazione Monza e Brianza per il Bambino e la sua Mamma, Ospedale San Gerardo, Monza, Italy.
J-H DalleHemato-Immunology Department, Robert-Debre Hospital, APHP and Paris-Diderot University, Paris, France.
K JahnukainenDivision of Hematology-Oncology and Stem Cell Transplantation, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
M von WolffDivision of Reproductive Medicine and Endocrinology, Department of Obstetrics and Gynecology, Inselspital Bern, University Hospital, Bern, Switzerland.
G LucchiniBone Marrow Transplant Department, Great Ormond Street Hospital, London, UK.
M IfversenDepartment of Pediatric and Adolescent Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
K T MacklonThe Fertility Clinic, Copenhagen University Hospital, Copenhagen, Denmark.
C PoirotAdolescent and Young Adult Hematology Unit, Saint Louis Hospital, Assistance Publique-Hôpitaux de Paris, University Pierre et Marie Curie, Paris, France.
T DieschDepartment of Pediatric Hematology/Oncology, University Children's Hospital of Basel, Basel, Switzerland.
A JarischDivision for Stem Cell Transplantation and Immunology, Department for Children and Adolescents, University Hospital, Goethe University Frankfurt am Main, Frankfurt, Germany.
D BrestersWillem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, The Netherlands.
I YanivPediatric Hematology Oncology, Schneider Children's Medical Center of Israel, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
B GibsonDepartment of Paediatric Haematology, Royal Hospital for Children, Scotland, UK.
A M WillaschDivision for Stem Cell Transplantation and Immunology, Department for Children and Adolescents, University Hospital, Goethe University Frankfurt am Main, Frankfurt, Germany.
R FadiniCentro di Medicina della Riproduzione Biogenesi, Istituti Clinici Zucchi, Monza, Italy.
L FerrariDepartment of Gynecology and Obstetrics, Ospedale San Gerardo di Monza, Monza, Italy.
A LawitschkaSt Anna Children's Hospital, UKKJ, MUW, Vienna, Austria.
A AhlerDivision of Reproductive Medicine and Endocrinology, Department of Obstetrics and Gynaecology, University Hospital, Basel, Switzerland.
N SängerDivision of Reproductive Medicine, Endocrinology and Infertility, Department of Obstetrics and Gynecology, University Hospital, JW Goethe University, Frankfurt, Germany.
S CorbaciogluDepartment of Pediatric Hematology, Oncology and Stem Cell Transplantation, University Hospital, University of Regensburg, Regensburg, Germany.
M AnsariDepartment of Pediatrics, Hémato-Oncologie Pédiatrique, CANSEARCH Research Laboratory, Université de Médecine de Genève, Geneva, Switzerland.
R MoffatDivision of Reproductive Medicine and Endocrinology, Department of Obstetrics and Gynaecology, University Hospital, Basel, Switzerland.
A DalissierEBMT Paris Office, Hospital Saint Antoine, Paris, France.
E BeohouEBMT Paris Office, Hospital Saint Antoine, Paris, France.
P SedlacekDepartment of Pediatric Hematology and Oncology, University Hospital Motol, Prague, Czech Republic.
A LankesterWillem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, The Netherlands.
C D De Heredia RubioPediatric Oncology and Hematology Department, Hospital Universitario Vall d'Hebron, Barcelona, Spain.
K VettenrantaDivision of Hematology-Oncology and Stem Cell Transplantation, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
J WachowiakDepartment of Pediatric Oncology, Hematology and Transplantology, University of Medical Sciences, Poznan, Poland.
A YesilipekBahcesehir University School of Medicine, Department of Pediatrics, Pediatric Stem Cell Transplantation Unit, Istanbul, Turkey.
E TrigosoPaediatric Oncology Unit, Paediatric Transplant Unit, Polytechnic and University Hospital 'LA FE', Valencia, Spain.
T KlingebielDivision for Stem Cell Transplantation and Immunology, Department for Children and Adolescents, University Hospital, Goethe University Frankfurt am Main, Frankfurt, Germany.
C PetersSt Anna Children's Hospital, UKKJ, MUW, Vienna, Austria.ORCID http://orcid.org/0000-0003-0369-8515
P BaderDivision for Stem Cell Transplantation and Immunology, Department for Children and Adolescents, University Hospital, Goethe University Frankfurt am Main, Frankfurt, Germany.
Goethe University Frankfurt · DEAzienda Ospedaliera San Gerardo · ITCopenhagen University Hospital · DKHôpital Saint-Antoine · FRLeiden University Medical Center · NLSt Anna Children's Hospital · ATUniversity Hospital of Basel · CHUniversity of Helsinki · FIAssistance Publique – Hôpitaux de Paris · FRBahçeşehir University · TRBiogen (Italy) · ITGreat Ormond Street Hospital · GBHospital Universitari i Politècnic La Fe · ESPoznan University of Medical Sciences · PLRoyal Hospital for Children · GBTel Aviv University · ILUniversité Paris Cité · FRUniversity Children’s Hospital Basel · CHUniversity Hospital in Motol · CZUniversity Hospital of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fertility preservation is an urgent challenge in the transplant setting. A panel of transplanters and fertility specialists within the Pediatric Diseases Working Party of the European Society for Blood and Marrow Transplantation (EBMT) and the International BFM Study Group provides specific guidelines. Patients and families should be informed of possible gender- and age-specific cryopreservation strategies that should be tailored according to the underlying disease, clinical condition and previous exposure to chemotherapy. Semen collection should be routinely offered to all postpubertal boys at the diagnosis of any disease requiring therapy that could potentially impair fertility. Testicular tissue collection might be offered to postpubertal boys; nevertheless, its use has been unsuccessful to date. Oocyte collection after hormonal hyperstimulation should be offered to postpubertal girls facing gonadotoxic therapies that could be delayed for the 2 weeks required for the procedure. Ovarian tissue collection could be offered to pre-/post-pubertal girls. Pregnancies have been reported after postpubertal ovarian tissue reimplantation; however, to date, no pregnancy has been reported after the reimplantation of prepubertal ovarian tissue or in vitro maturation of pre-/post-pubertal ovarian tissue. Possible future advances in reproductive medicine could change this scenario. Health authorities should prioritize fertility preservation projects in pediatric transplantation to improve patient care and quality of life.

Indexed as

Antineoplastic AgentsCryopreservationFertility PreservationHematopoietic Stem Cell TransplantationOvaryTestisAdolescentAllograftsChildFemaleHumansMaleAntineoplastic Agents

Identifiers

PMID28737775
OpenAlexW2738442683

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.