ArticleNature cell biology2017
Local lung hypoxia determines epithelial fate decisions during alveolar regeneration.
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Article in Nature cell biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 184 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
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184citing papers in PubMed, 1 pooled it
17.6field-weighted citation impact, top 1% of its field
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Who cites it
184 citing papers in PubMed, 1 synthesis or guideline pooled it, 277 citations in OpenAlex.
- Current strategies and opportunities to manufacture cells for modeling human lungs.Advanced drug delivery reviews · 2020Pooled it
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- Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66cAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Influenza-induced tuft cell expansion is associated with changes in ILC2 populations in the distal lungs of mice.Physiological reports · 2026Article
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- Long noncoding RNA#61 synergizes with viral PA-X to augment pyroptosis and attenuate the virulence of highly pathogenic H5N1 influenza virus in mice.Journal of virology · 2026Article
- Epigenetic de-repression of basal cell metaplasia in aging AT2 cells is a risk factor for idiopathic pulmonary fibrosis (IPF).bioRxiv : the preprint server for biology · 2026Article
- Chronic TGFβ1 Signaling Drives Aberrant Alveolar-Basaloid Metaplasia through a KRT17-Stratifin migratory complex.bioRxiv : the preprint server for biology · 2026Article
- Influenza-induced tuft cell expansion alters ILC-mediated inflammation.bioRxiv : the preprint server for biology · 2026Article
- Unlocking Alveolar Regeneration: AT2 Stem Cells, Signaling Networks, and Therapeutic Frontiers.Stem cell reviews and reports · 2026Review
- Dysplastic Epithelial Repair Propagates Chronic Pathology Through the Paracrine Transformation of Pulmonary Fibroblasts.bioRxiv : the preprint server for biology · 2026Article
- Alveolar-Basal Intermediates Drive Pulmonary Fibrosis via Coordination of a Pro-Fibrotic Signaling Niche in Silicosis.bioRxiv : the preprint server for biology · 2026Article
- Airway basal stem cell derived extracellular vesicles promote lung repair in chronic obstructive pulmonary disease.Regenerative therapy · 2026Article
- New approaches to uncover COPD pathobiology and develop therapies.JCI insight · 2026Review
- Control of airway basal stem cell-mediated lung repair by TGF-β signaling.Science advances · 2026Article
- Alveolar dysregulation of host response in pneumonia and ARDS: implications for immune modulation and infection.Annals of intensive care · 2026Review
- Modulation of an aberrant basal cell program in human alveolar epithelial spheroids and lung slices.Respiratory research · 2025Article
- Lineage Tracing of Distal Lung Epithelial Progenitors in Injury-Induced Regeneration.The clinical respiratory journal · 2025Review
124 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Ying XiDepartment of Medicine, Cardiovascular Research Institute, UCSF, San Francisco, California 94143, USA.
Thomas KimDepartment of Medicine, Cardiovascular Research Institute, UCSF, San Francisco, California 94143, USA.
Alexis N BrumwellDepartment of Medicine, Cardiovascular Research Institute, UCSF, San Francisco, California 94143, USA.
Ian H DriverDepartment of Anatomy, UCSF, San Francisco, California 94143, USA.
Ying WeiDepartment of Medicine, Cardiovascular Research Institute, UCSF, San Francisco, California 94143, USA.
Victor TanDepartment of Medicine, Cardiovascular Research Institute, UCSF, San Francisco, California 94143, USA.
Julia R JacksonDepartment of Medicine, Cardiovascular Research Institute, UCSF, San Francisco, California 94143, USA.
Jianming XuDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.
Dong-Kee LeeDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.
Jeffrey E GottsDepartment of Medicine, Cardiovascular Research Institute, UCSF, San Francisco, California 94143, USA.
Michael A MatthayDepartment of Medicine, Cardiovascular Research Institute, UCSF, San Francisco, California 94143, USA.
John M ShannonDivision of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.
Harold A ChapmanDepartment of Medicine, Cardiovascular Research Institute, UCSF, San Francisco, California 94143, USA.ORCID http://orcid.org/0000-0002-5280-5527
Andrew E VaughanDepartment of Medicine, Cardiovascular Research Institute, UCSF, San Francisco, California 94143, USA.
University of California, San Francisco · USBaylor College of Medicine · USCincinnati Children's Hospital Medical Center · US
Funding
MUTIDISCIPLINARY TRAINING PROGRAM IN LUNG DISEASEST32HL007185 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI David J Erle, LAURENCE HUANG · 1985 to 2026
$24.6MEpithelial stem/progenitor cells as repair agents in diffuse alveolar damageU01HL134766 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAPMAN, HAROLD A, KOTTON, DARRELL N. · 2016 to 2022
$8.1MUMDNJ TRAINING GRANT IN BIOTECHNOLOGYT32GM008339 · NIGMS · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI YARMUSH, MARTIN L · 1989 to 2019
$6.1MResolution of Clinical Lung InjuryR37HL051856 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHAY, MICHAEL A. · 2006 to 2015
$3.9MEpithelial Progenitor Cells in Lung Repair and RegenerationU01HL111054 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAPMAN, HAROLD A, CHUANG, PAO-TIEN · 2012 to 2016
$3.2MThe Role of SRC-1 in Breast CancerR01CA112403 · NCI · BAYLOR COLLEGE OF MEDICINE · PI XU, JIANMING · 2006 to 2016
$2.9MRole of HIF-1alpha in Fetal Lung Epithelial DifferentiationR01HL084376 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI SHANNON, JOHN M · 2007 to 2011
$2.7MEpithelial Stem/Progenitor Cells in Repair of the Injured LungR01HL128484 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAPMAN, HAROLD A · 2015 to 2019
$2.5MNCOA6, A Novel Tumor Suppressor of Endometrial CancerR01CA193455 · NCI · BAYLOR COLLEGE OF MEDICINE · PI XU, JIANMING · 2016 to 2021
$1.9MHeterogeneity and Bias of Lineage Negative Progenitors in Lung Epithelial Repair R00HL131817 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI VAUGHAN, ANDREW · 2017 to 2019
$722kHeterogeneity and bias of lineage negative progenitors in lung epithelial repairK99HL131817 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VAUGHAN, ANDREW · 2016 to 2017
$319kRegenerative Role of Integrin Beta4pos p63pos Distal Lung Stem/Progenitor CellsF32HL117600 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VAUGHAN, ANDREW · 2014 to 2014
$55kNCI NIH HHS R01 CA112403NCI NIH HHS R01 CA193455NHLBI NIH HHS F32 HL117600NHLBI NIH HHS K99 HL131817NHLBI NIH HHS R00 HL131817NHLBI NIH HHS R01 HL084376NHLBI NIH HHS R01 HL128484NHLBI NIH HHS R37 HL051856NHLBI NIH HHS T32 HL007185NHLBI NIH HHS U01 HL111054NHLBI NIH HHS U01 HL134766NIGMS NIH HHS T32 GM008339
Abstract
After influenza infection, lineage-negative epithelial progenitors (LNEPs) exhibit a binary response to reconstitute epithelial barriers: activating a Notch-dependent ΔNp63/cytokeratin 5 (Krt5) remodelling program or differentiating into alveolar type II cells (AEC2s). Here we show that local lung hypoxia, through hypoxia-inducible factor (HIF1α), drives Notch signalling and Krt5
Indexed as
Cell LineageCell ProliferationCell TransdifferentiationRegenerationAnimalsCell MovementCells, CulturedDisease Models, AnimalEpithelial CellsFemaleGene Expression ProfilingGenotypeHumansHypoxiaHypoxia-Inducible Factor 1, alpha SubunitInfluenza A Virus, H1N1 SubtypeHIF1A protein, humanHif1a protein, mouseHypoxia-Inducible Factor 1, alpha SubunitKeratin-5KRT5 protein, humanOxygenPhosphoproteinsReceptors, NotchSOX2 protein, humanSox2 protein, mouseSOXB1 Transcription FactorsTP63 protein, humanTrans-ActivatorsTranscription FactorsTrp63 protein, mouseTumor Suppressor Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.