ArticleNature microbiology2017
Biphasic growth dynamics control cell division in Caulobacter crescentus.
Article in Nature microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 61 citations in OpenAlex.
- Identification, functional characterization of a novel flavohemoglobin from Ensifer adhaerens and its application to enhancing vitamin BMicrobial cell factories · 2026Article
- Gene expression cycles drive non-exponential bacterial growth.Physical review research · 2025Article
- Article
- Roles of Different Signaling Pathways inJournal of fungi (Basel, Switzerland) · 2024Review
- Engineered Cell Elongation Promotes Extracellular Electron Transfer of Shewanella Oneidensis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Coupling of cell growth modulation to asymmetric division and cell cycle regulation inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Differential growth regulates asymmetric size partitioning inLife science alliance · 2024Article
- Mechanical control of cell proliferation patterns in growing epithelial monolayers.Biophysical journal · 2024Article
- Energy allocation theory for bacterial growth control in and out of steady state.bioRxiv : the preprint server for biology · 2024Article
- Super-exponential growth and stochastic size dynamics in rod-like bacteria.Biophysical journal · 2023Article
- Cellular resource allocation strategies for cell size and shape control in bacteria.The FEBS journal · 2022Review
- Article
- Probing bacterial cell wall growth by tracing wall-anchored protein complexes.Nature communications · 2021Article
- Modeling homeostasis mechanisms that set the target cell size.Scientific reports · 2020Article
- Untargeted metabolomics links glutathione to bacterial cell cycle progression.Nature metabolism · 2020Article
- Reassessment of the Basis of Cell Size Control Based on Analysis of Cell-to-Cell Variability.Biophysical journal · 2019Article
- Microfluidic time-lapse analysis and reevaluation of the Bacillus subtilis cell cycle.MicrobiologyOpen · 2019Article
- Article
- Article
- Constriction Rate Modulation Can Drive Cell Size Control and Homeostasis in C. crescentus.iScience · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell size is specific to each species and impacts cell function. Various phenomenological models for cell size regulation have been proposed, but recent work in bacteria has suggested an 'adder' model, in which a cell increments its size by a constant amount between each division. However, the coupling between cell size, shape and constriction remains poorly understood. Here, we investigate size control and the cell cycle dependence of bacterial growth using multigenerational cell growth and shape data for single Caulobacter crescentus cells. Our analysis reveals a biphasic mode of growth: a relative timer phase before constriction where cell growth is correlated to its initial size, followed by a pure adder phase during constriction. Cell wall labelling measurements reinforce this biphasic model, in which a crossover from uniform lateral growth to localized septal growth is observed. We present a mathematical model that quantitatively explains this biphasic 'mixer' model for cell size control.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.