Evidence map›Paper›PMID 28737608›Full record

Trial reportOptometry and vision science : official publication of the American Academy of Optometry2017

A Randomized Trial of Soft Multifocal Contact Lenses for Myopia Control: Baseline Data and Methods.

Jeffrey J Walline, Amber Gaume Giannoni, Loraine T Sinnott, Moriah A Chandler, Juan Huang, Donald O Mutti, Lisa A Jones-Jordan, David A Berntsen, BLINK Study Group

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Optometry and vision science : official publication of the American Academy of Optometry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 2 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.

  1. Interventions to slow progression of myopia in children.The Cochrane database of systematic reviews · 2020
    Pooled it
  2. Pooled it
  3. Frequency of retinal findings after 8 years in the Bifocal Lenses in Nearsighted Kids (BLINK) Study.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025
    Trial
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Bifocal & Atropine in Myopia Study: Baseline Data and Methods.Optometry and vision science : official publication of the American Academy of Optometry · 2019
    Trial
  10. Visual Acuity and Over-refraction in Myopic Children Fitted with Soft Multifocal Contact Lenses.Optometry and vision science : official publication of the American Academy of Optometry · 2018
    Trial
  11. Power Profiles of an Extended Depth of Focus Contact Lens for Myopia Management.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
    Article
  12. Article
  13. Review
  14. Accommodative behaviour and retinal defocus in highly myopic eyes fitted with a dual focus myopia control contact lens.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025
    Article
  15. Peripheral refraction of young adults with myopia: a cross-sectional study.The Journal of international medical research · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Quality of life after wearing multifocal contact lenses for myopia control for 2 weeks in the BLINK Study.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 7 countries.

Jeffrey J Walline1The Ohio State University College of Optometry, Columbus, Ohio 2University of Houston College of Optometry, Houston, Texas.
Amber Gaume Giannoni
Loraine T Sinnott
Moriah A Chandler
Juan Huang
Donald O Mutti
Lisa A Jones-Jordan
David A Berntsen
BLINK Study Group
The Ohio State University · USUniversity of Houston · USChengdu Surveying Geotechnical Research Institute · CNThe Coordinating Center · USUniversitas Jember · ID

Funding

The Ohio State University Center for clinical and Translational ScienceUL1TR001070 · NCATS · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2013 to 2017
$22.6M
Research Programming ModuleP30EY007551 · NEI · UNIVERSITY OF HOUSTON · PI LAURA J. FRISHMAN · 1988 to 2026
$16.4M
Soft Bifocal Contact Lens Myopia Control - Clincal CenterU10EY023210 · NEI · OHIO STATE UNIVERSITY · PI MUTTI, DONALD O. · 2014 to 2018
$2.9M
Soft Bifocal Contact Lens Myopia ControlU10EY023204 · NEI · UNIVERSITY OF HOUSTON · PI BERNTSEN, DAVID A · 2014 to 2018
$2.6M
Examination of Myopia Progression and Consequences and Mechanism of Soft Multifocal Contact Lens Myopia Control - Clinical CenterUG1EY023210 · NEI · OHIO STATE UNIVERSITY · PI MUTTI, DONALD O. · 2019 to 2023
$2.6M
Soft Bifocal Contact Lens Myopia Control - Data Coordinating CenterU10EY023206 · NEI · OHIO STATE UNIVERSITY · PI JORDAN, LISA A · 2014 to 2018
$1.8M
Examination of Myopia Progression and Consequences and Mechanism of Soft Multifocal Contact Lens Myopia Control - Data Coordinating CenterUG1EY023206 · NEI · OHIO STATE UNIVERSITY · PI JORDAN, LISA A · 2019 to 2023
$1.4M
Soft Bifocal Contact Lens Myopia Control - Study ChairU10EY023208 · NEI · OHIO STATE UNIVERSITY · PI WALLINE, JEFFREY JAY · 2014 to 2018
$742k
Examination of Myopia Progression and Consequences and Mechanism of Soft Multifocal Contact Lens Myopia ControlUG1EY023208 · NEI · OHIO STATE UNIVERSITY · PI WALLINE, JEFFREY JAY · 2019 to 2023
$678k
NCATS NIH HHS UL1 TR001070NEI NIH HHS P30 EY007551NEI NIH HHS U10 EY023204NEI NIH HHS U10 EY023206NEI NIH HHS U10 EY023208NEI NIH HHS U10 EY023210NEI NIH HHS UG1 EY023206NEI NIH HHS UG1 EY023208NEI NIH HHS UG1 EY023210
6 · The paper itself

Abstract

significanceThe Bifocal Lenses In Nearsighted Kids (BLINK) study is the first soft multifocal contact lens myopia control study to compare add powers and measure peripheral refractive error in the vertical meridian, so it will provide important information about the potential mechanism of myopia control. PURPOSE: The BLINK study is a National Eye Institute-sponsored, double-masked, randomized clinical trial to investigate the effects of soft multifocal contact lenses on myopia progression. This article describes the subjects' baseline characteristics and study methods.

methodsSubjects were 7 to 11 years old, had -0.75 to -5.00 spherical component and less than 1.00 diopter (D) astigmatism, and had 20/25 or better logMAR distance visual acuity with manifest refraction in each eye and with +2.50-D add soft bifocal contact lenses on both eyes. Children were randomly assigned to wear Biofinity single-vision, Biofinity Multifocal "D" with a +1.50-D add power, or Biofinity Multifocal "D" with a +2.50-D add power contact lenses.

resultsWe examined 443 subjects at the baseline visits, and 294 (66.4%) subjects were enrolled. Of the enrolled subjects, 177 (60.2%) were female, and 200 (68%) were white. The mean (± SD) age was 10.3 ± 1.2 years, and 117 (39.8%) of the eligible subjects were younger than 10 years. The mean spherical equivalent refractive error, measured by cycloplegic autorefraction was -2.39 ± 1.00 D. The best-corrected binocular logMAR visual acuity with glasses was +0.01 ± 0.06 (20/21) at distance and -0.03 ± 0.08 (20/18) at near.

conclusionsThe BLINK study subjects are similar to patients who would routinely be eligible for myopia control in practice, so the results will provide clinical information about soft bifocal contact lens myopia control as well as information about the mechanism of the treatment effect, if one occurs.

Indexed as

Contact LensesVisual AcuityChildDisease ProgressionDouble-Blind MethodFemaleFollow-Up StudiesHumansMaleMyopiaRefraction, OcularTime FactorsTreatment OutcomeVision Tests

Identifiers

PMID28737608
PMCPMC5607949
OpenAlexW2739229014

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.