Evidence map›Paper›PMID 28737214›Full record

ArticleThe Journal of physiology2017

Decline in cellular function of aged mouse c-kit

Alessandra Castaldi, Ramsinh Mansinh Dodia, Amabel M Orogo, Cristina M Zambrano, Rita H Najor, Åsa B Gustafsson, Joan Heller Brown, Nicole H Purcell

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 33 citations in OpenAlex.

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  18. Adult Cardiac Stem Cell Aging: A Reversible Stochastic Phenomenon?Oxidative medicine and cellular longevity · 2019
    Review
  19. Article
  20. Inhibition of p16Stem cell reviews and reports · 2018
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Alessandra CastaldiDepartment of Pharmacology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-6616-6519
Ramsinh Mansinh DodiaDepartment of Pharmacology, University of California, San Diego, La Jolla, CA, USA.
Amabel M OrogoDepartment of Pharmacology, University of California, San Diego, La Jolla, CA, USA.
Cristina M ZambranoDepartment of Pharmacology, University of California, San Diego, La Jolla, CA, USA.
Rita H NajorDepartment of Pharmacology, University of California, San Diego, La Jolla, CA, USA.
Åsa B GustafssonDepartment of Pharmacology, University of California, San Diego, La Jolla, CA, USA.
Joan Heller BrownDepartment of Pharmacology, University of California, San Diego, La Jolla, CA, USA.
Nicole H PurcellDepartment of Pharmacology, University of California, San Diego, La Jolla, CA, USA.
University of California San Diego · USCalifornia State University, Channel Islands · US

Funding

Surgery, Physiology and ImmunohistopathologyP01HL085577 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI SUSSMAN, MARK ALAN · 2006 to 2017
$18.4M
GRADUATE TRAINING IN CELLULAR &MOLECULAR PHARMACOLOGYT32GM007752 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROWN, JOAN HELLER, HANDEL, TRACY M · 1985 to 2023
$13.5M
Role of PHLPP in the HeartR01HL114949 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PURCELL, NICOLE H · 2014 to 2022
$3.7M
Mitochondrial Quality Control is Essential for Cardiac Progenitor Cell FunctionF31HL123309 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI OROGO, AMABEL · 2014 to 2016
$98k
NHLBI NIH HHS F31 HL123309NHLBI NIH HHS P01 HL085577NHLBI NIH HHS R01 HL114949NIGMS NIH HHS T32 GM007752
6 · The paper itself

Abstract

key pointsWhile autologous stem cell-based therapies are currently being tested on elderly patients, there are limited data on the function of aged stem cells and in particular c-kit ABSTRACT: Therapeutic use of c-kit

Indexed as

Cellular SenescenceAdult Stem CellsAgingAnimalsCell DifferentiationCell ProliferationCells, CulturedDexamethasoneElectron Transport Chain Complex ProteinsGATA Transcription FactorsMaleMEF2 Transcription FactorsMiceMice, Inbred C57BLMyocytes, CardiacOrganelle BiogenesisDexamethasoneElectron Transport Chain Complex ProteinsGATA Transcription FactorsLin-28 protein, mouseMef2c protein, mouseMEF2 Transcription FactorsPlatelet Endothelial Cell Adhesion Molecule-1Proto-Oncogene Proteins c-kitRNA-Binding ProteinsRNA, Messengeragingcardiac progenitor cellsc-kitstem cell

Identifiers

PMID28737214
PMCPMC5621489
OpenAlexW2736842962

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.