ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2019
Functional and structural alterations in the migraine cerebellum.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed, 1 synthesis or guideline pooled it, 137 citations in OpenAlex.
- Sensorimotor Integration and Pain Perception: Mechanisms Integrating Nociceptive Processing. A Systematic Review and ALE-Meta Analysis.Frontiers in integrative neuroscience · 2022Pooled it
- The effect of erenumab on brain network function in episodic migraine patients: a randomized, placebo-controlled clinical trial (RESET BRAIN).Journal of neurology · 2023Trial
- Cerebrovascular reactivity in migraine: a breath-hold BOLD fMRI study.The journal of headache and pain · 2026Observational
- Abnormal functional activity in the cerebellar crus can distinguish patients with migraine with comorbid insomnia.Frontiers in neuroscience · 2026Article
- Brain networks activated when aggravating baseline chronic pain of an individual with new daily persistent headache: a case study.BMC neurology · 2025Article
- Integrated ATAC-seq and RNA-seq analysis identifies Grid2 and Reln as potential regulatory genes in migraine pathophysiology.The journal of headache and pain · 2025Article
- Altered Topology of Brain Structural Network in Patients With Migraine Without Aura: A Structural MRI Study.European journal of pain (London, England) · 2025Article
- Evidence for brain glial activity in chronic migraine patients: a [European journal of nuclear medicine and molecular imaging · 2025Article
- Functional and Structural Differences of Brain in Patients With Vestibular Migraine: A Resting-State Functional MRI and DTI Study.Brain and behavior · 2025Article
- Cluster Headache and Migraine Shared and Unique Insights: Neurophysiological Implications, Neuroimaging, and Biomarkers: A Comprehensive Review.Journal of clinical medicine · 2025Review
- Neural correlates of pain acceptance and the role of the cerebellum: Functional connectivity and anatomical differences in individuals with headaches versus matched controls.European journal of pain (London, England) · 2025Article
- Potential neural mechanisms of acupuncture therapy on migraine: a systematic review and activation likelihood estimation meta-analysis update.Quantitative imaging in medicine and surgery · 2025Article
- Local Dynamic Stability of Trunk During Gait Can Detect Dynamic Imbalance in Subjects with Episodic Migraine.Sensors (Basel, Switzerland) · 2024Article
- Disrupted topologic efficiency of white matter structural connectome in migraine: a graph-based connectomics study.The journal of headache and pain · 2024Article
- Phasic perfusion dynamics among migraine subtypes: a multimodel arterial spin labeling investigation.The journal of headache and pain · 2024Article
- Iron Deposition and Functional Connectivity Differences in Females With Migraine Without Aura: A Comparative Study of Headache Sides.Brain and behavior · 2024Article
- Involvement of the cerebellum in structural connectivity enhancement in episodic migraine.The journal of headache and pain · 2024Article
- Gamma-aminobutyric acid and glutamate/glutamine levels in the dentate nucleus and periaqueductal gray in new daily persistent headache: a magnetic resonance spectroscopy study.The journal of headache and pain · 2024Article
- Brain connectome-based imaging markers for identifiable signature of migraine with and without aura.Quantitative imaging in medicine and surgery · 2024Article
- Volumetric Differences in Cerebellum and Brainstem in Patients with Migraine: A UK Biobank Study.Biomedicines · 2023Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cerebellum plays an important role in pain processing but its function in headache and specifically in migraine is not known. We therefore compared 54 migraineurs with pairwise matched healthy controls in a magnetic resonance imaging study on neuronal cerebellar activity in response to nociceptive trigeminal sensation and also investigated possible structural alterations. Headache frequency, disease duration, and the proximity to a migraine attack were used as co-factors. Migraine patients showed functional and structural alterations in the posterior part of the cerebellum, namely crus I and crus II. Gray matter volume changes were seen on the right side whereas functional changes were ipsilateral to the stimulation, on the left side. Neuronal activity in the crus in response to trigeminal pain was modulated by migraine severity and the migraine phase. As the crus is strongly interconnected to higher cognitive areas in the temporal, frontal, and parietal part of the cortex our results suggest an specific cerebellar involvement in migraine. This is further supported by our finding of decreased connectivity from the crus to the thalamus and higher cortical areas in the patients. We therefore suggest an abnormally decreased inhibitory involvement of the migraine cerebellum on gating and nociceptive evaluation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.