Evidence map›Paper›PMID 28736993›Full record

ArticleMicrobiology and immunology2017

Molecular characterization of Streptococcus pneumoniae, particularly serotype19A/ST320, which emerged in Krasnoyarsk, Russia.

Irina N Protasova, Tsai-Wen Wan, Natalya V Bakhareva, Wei-Chun Hung, Wataru Higuchi, Yasuhisa Iwao, Tatyana A Yelistratova, Natalya A Ilyenkova, Yelena S Sokolovskaya, Galina P Martynova and 7 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology and immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 3 countries.

Irina N ProtasovaRussia-Japan Center of Microbiology, Metagenomics and Infectious Diseases, Krasnoyarsk, Russia.
Tsai-Wen WanDepartment of Epidemiology, Genomics, and Evolution, International Medical Education and Research, Center Niigata, Japan.
Natalya V BakharevaKrasnoyarsk State Ministry of Healthcare, Krasnoyarsk, Russia.
Wei-Chun HungDepartment of Epidemiology, Genomics, and Evolution, International Medical Education and Research, Center Niigata, Japan.
Wataru HiguchiDivision of Bacteriology, Department of Infectious Disease Control and International Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Yasuhisa IwaoDepartment of Epidemiology, Genomics, and Evolution, International Medical Education and Research, Center Niigata, Japan.
Tatyana A YelistratovaDepartment of Infectious Diseases, Krasnoyarsk, Russia.
Natalya A IlyenkovaDepartment of Children Diseases, Krasnoyarsk, Russia.
Yelena S SokolovskayaDepartment of Children Diseases, Krasnoyarsk, Russia.
Galina P MartynovaDepartment of Children Infectious Diseases, Krasnoyarsk State Medical University, Krasnoyarsk, Russia.
Ivan V RevaDepartment of Epidemiology, Genomics, and Evolution, International Medical Education and Research, Center Niigata, Japan.
Galina V RevaDepartment of Clinical and Fundamental Medicine, Far Eastern Federal University School of Biomedicine, Vladivostok, Russia.
Sergey V SidorenkoResearch Institute of Children Infections of Federal State Medical and Biological Agency of Russia, Saint Petersburg.
Lee-Jene TengDepartment of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan.
Olga V PeryanovaRussia-Japan Center of Microbiology, Metagenomics and Infectious Diseases, Krasnoyarsk, Russia.
Alla B SalminaResearch Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State Medical University, Krasnoyarsk, Russia.
Tatsuo YamamotoRussia-Japan Center of Microbiology, Metagenomics and Infectious Diseases, Krasnoyarsk, Russia.
Krasnoyarsk State Medical University · RUKrasnoyarsk Scientific Center · RUFar Eastern Federal University · RUNational Taiwan University · TWChildren's Scientific and Clinical Center for Infectious Diseases of the Federal Medical and Biological Agency · RUKaohsiung Medical University · TWNiigata University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Streptococcus pneumoniae, a common human pathogen, colonizes the nasopharynx and causes diseases including acute otitis media (AOM). Herein, pneumococcal serotype distributions in children before and after PCV7 vaccination and in patients with pneumococcal disease in Siberian Russia (Krasnoyarsk) are reported. Analyses included antimicrobial susceptibility testing, sequence typing (ST), pulsed field gel electrophoresis, virulence-related surface protein gene (VSG) typing with novel primers and structural analysis by scanning electron microscopy. In healthy children (HC) prior to administration of PCV7, drug-susceptible serotype23F/ST1500 was a major pneumococcal genotype. In the PCV7 trial, multidrug-resistant serotype19A/ST320 emerged in vaccinees after PCV7, exhibiting a PCV7-induced serotype replacement. Multidrug-resistant serotype19A/ST320 was evident in patients with AOM. Community-acquired pneumonia (CAP) isolates showed genetic similarities to the AOM (ST320) genotype, constituting a common non-invasive AOM-CAP group. In contrast, meningitis isolates were more divergent. Overall, 25 ST types were identified; five (20%) of which were Krasnoyarsk-native. Regarding VSGs, PI-1 (rlrA/rrgB), PI-2 (pitA/B), psrP and cbpA were present at 54.3%, 38.6%, 48.6%, and 95.7%, respectively, with two major VSG content types, PI-1

Indexed as

Bacterial AdhesionCell LineChild, PreschoolFimbriae, BacterialHeptavalent Pneumococcal Conjugate VaccineHumansMicrobial Sensitivity TestsMicroscopy, Electron, ScanningMultilocus Sequence TypingOtitis MediaPneumococcal InfectionsRussiaSiberiaStreptococcus pneumoniaeVaccinationVirulence FactorsHeptavalent Pneumococcal Conjugate VaccineVirulence Factorscapsule/ST/surface protein gene typePCV7 vaccinationpneumococcal wire (pilus) structureStreptococcus pneumoniae

Identifiers

PMID28736993
PMCPMC5639370
OpenAlexW2738798927

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.