Evidence map›Paper›PMID 28736855›Full record

ReviewBritish journal of pharmacology2017

'Lnc'-ing Wnt in female reproductive cancers: therapeutic potential of long non-coding RNAs in Wnt signalling.

Mei S Ong, Wanpei Cai, Yi Yuan, Hin C Leong, Tuan Z Tan, Asad Mohammad, Ming L You, Frank Arfuso, Boon C Goh, Sudha Warrier and 7 more

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in British journal of pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Unraveling the Potential Role of NEDD4-like E3 Ligases in Cancer.International journal of molecular sciences · 2022
    Review
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  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Role of long non-coding RNAs (LncRNAs) in multiple sclerosis: a brief review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
    Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 5 countries.

Mei S OngDepartments of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Wanpei CaiDepartments of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Yi YuanCancer Science Institute of Singapore, National University of Singapore, Singapore.
Hin C LeongDepartments of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Tuan Z TanCancer Science Institute of Singapore, National University of Singapore, Singapore.
Asad MohammadCancer Science Institute of Singapore, National University of Singapore, Singapore.
Ming L YouCancer Science Institute of Singapore, National University of Singapore, Singapore.
Frank ArfusoStem Cell and Cancer Biology Laboratory, School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, WA, Australia.
Boon C GohDepartments of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Sudha WarrierDivision of Cancer Stem Cells and Cardiovascular Regeneration, Manipal Institute of Regenerative Medicine, Manipal University, Bangalore, India.
Gautam SethiDepartments of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Nicholas S TolwinskiDivision of Science, Yale-NUS College, Singapore.
Peter E LobieDepartments of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Celestial T YapDepartments of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Shing C HooiDepartments of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Ruby Y HuangDepartments of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Alan P KumarDepartments of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.ORCID http://orcid.org/0000-0002-3754-5712
National University of Singapore · SGCurtin University · AUManipal Academy of Higher Education · INUniversity of North Texas · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent discoveries in the non-coding genome have challenged the original central dogma of molecular biology, as non-coding RNAs and related processes have been found to be important in regulating gene expression. MicroRNAs and long non-coding RNAs (lncRNAs) are among those that have gained attention recently in human diseases, including cancer, with the involvement of many more non-coding RNAs (ncRNAs) waiting to be discovered. ncRNAs are a group of ribonucleic acids transcribed from regions of the human genome, which do not become translated into proteins, despite having essential roles in cellular physiology. Deregulation of ncRNA expression and function has been observed in cancer pathogenesis. Recently, the roles of a group of ncRNA known as lncRNA have gained attention in cancer, with increasing reports of their oncogenic involvement. Female reproductive cancers remain a leading cause of death in the female population, accounting for almost a third of all female cancer deaths in 2016. The Wnt signalling pathway is one of the most important oncogenic signalling pathways which is hyperactivated in cancers, including female reproductive cancers. The extension of ncRNA research into their mechanistic roles in human cancers has also led to novel reported roles of ncRNAs in the Wnt pathway and Wnt-mediated oncogenesis. This review aims to provide a critical summary of the respective roles and cellular functions of Wnt-associated lncRNAs in female reproductive cancers and explores the potential of circulating cell-free lncRNAs as diagnostic markers and lncRNAs as therapeutic targets. LINKED ARTICLES: This article is part of a themed section on WNT Signalling: Mechanisms and Therapeutic Opportunities. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.24/issuetoc.

Indexed as

FemaleHumansMicroRNAsOvarian NeoplasmsRNA, Long NoncodingWnt Signaling PathwayMicroRNAsRNA, Long Noncoding

Identifiers

PMID28736855
PMCPMC5727316
OpenAlexW2738730689

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.