ArticleCardiorenal medicine2017
Urinary Osteopontin Predicts Incident Chronic Kidney Disease, while Plasma Osteopontin Predicts Cardiovascular Death in Elderly Men.
Article in Cardiorenal medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 0 citations in OpenAlex.
- The fat-heart entanglement and the role of 'osteopontin mechanics' in cardiometabolic senescence.European journal of clinical investigation · 2026Review
- Enhancing therapeutic strategies and drug development for patients with kidney disease.Expert opinion on drug safety · 2026Review
- Inflammation-induced osteogenic signaling promotes calcium phosphate crystal formation in kidneys via MAPK, NF-κB, and smad pathways.Frontiers in cell and developmental biology · 2026Article
- Meprin β regulates osteopontin-signaling in ischemia/reperfusion-induced kidney injury.BMC nephrology · 2025Article
- Associations between plasma osteopontin, sex, and 2-year global and cardiorenal outcomes in older outpatients screened for CKD: a secondary analysis of the SCOPE study.Clinical kidney journal · 2024Article
- The association between novel urinary kidney damage biomarkers and coronary atherosclerosis in an apparently healthy population.Scientific reports · 2024Article
- Immunoregulatory Roles of Osteopontin in Diseases.Nutrients · 2024Review
- Urine-Based Detection of Biomarkers Indicative of Chronic Kidney Disease in a Patient Cohort from Ghana.Journal of personalized medicine · 2022Article
- Identification of osteopontin as a urinary biomarker for autosomal dominant polycystic kidney disease progression.Kidney research and clinical practice · 2022Article
- Assessment of biomarkers of early kidney damage and exposure to pollutants in artisanal mercury mining workers from Mexico.Environmental science and pollution research international · 2022Article
- The Most Promising Biomarkers of Allogeneic Kidney Transplant Rejection.Journal of immunology research · 2022Review
- Strong Associations between Plasma Osteopontin and Several Inflammatory Chemokines, Cytokines, and Growth Factors.Biomedicines · 2021Article
- Exposure to polycyclic aromatic hydrocarbon mixtures and early kidney damage in Mexican indigenous population.Environmental science and pollution research international · 2021Article
- Combining Neprilysin Inhibitor With ATFrontiers in pharmacology · 2021Article
- Assessment of kidney health and exposure to mixture pollutants in the Mexican indigenous population.Environmental science and pollution research international · 2020Article
- Urine biomarkers of chronic kidney damage and renal functional decline in childhood-onset systemic lupus erythematosus.Pediatric nephrology (Berlin, Germany) · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesThe matricellular protein osteopontin is involved in the pathogenesis of both kidney and cardiovascular disease. However, whether circulating and urinary osteopontin levels are associated with the risk of these diseases is less studied. DESIGN SETTING PARTICIPANTS AND MEASUREMENTS: A community-based cohort of elderly men (Uppsala Longitudinal Study of Adult Men [ULSAM];
resultsThere was no significant cross-sectional correlation between plasma and urinary osteopontin (Spearman ρ = 0.07,
conclusionsHigher urinary osteopontin specifically predicts incident chronic kidney disease, while plasma osteopontin specifically predicts cardiovascular death. Our data put forward osteopontin as an important factor in the detrimental interplay between the kidney and the cardiovascular system. The clinical implications, and why plasma and urinary osteopontin mirror different pathologies, remain to be established.
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