Evidence map›Paper›PMID 28736556›Full record

ArticleFrontiers in immunology2017

Ras Signaling Inhibitors Attenuate Disease in Adjuvant-Induced Arthritis

Morad Zayoud, Victoria Marcu-Malina, Einav Vax, Jasmine Jacob-Hirsch, Galit Elad-Sfadia, Iris Barshack, Yoel Kloog, Itamar Goldstein

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 30 citations in OpenAlex.

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  4. CD40 induces selective routing of Ras isoforms to subcellular compartments.Journal of cell communication and signaling · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Morad ZayoudSheba Cancer Research Center, Chaim Sheba Academic Medical Center, Ramat Gan, Israel.
Victoria Marcu-MalinaSheba Cancer Research Center, Chaim Sheba Academic Medical Center, Ramat Gan, Israel.
Einav VaxSheba Cancer Research Center, Chaim Sheba Academic Medical Center, Ramat Gan, Israel.
Jasmine Jacob-HirschSheba Cancer Research Center, Chaim Sheba Academic Medical Center, Ramat Gan, Israel.
Galit Elad-SfadiaDepartment of Neurobiology, The George S. Wise Faculty of Life Sciences & Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel.
Iris BarshackInstitute of Pathology, Chaim Sheba Academic Medical Center, Ramat Gan, Israel.
Yoel KloogDepartment of Neurobiology, The George S. Wise Faculty of Life Sciences & Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel.
Itamar GoldsteinSheba Cancer Research Center, Chaim Sheba Academic Medical Center, Ramat Gan, Israel.
Tel Aviv University · ILSheba Medical Center · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Ras family of GTPases plays an important role in signaling nodes downstream to T cell receptor and CD28 activation, potentially lowering the threshold for T-cell receptor activation by autoantigens. Somatic mutation in

Indexed as

adjuvant induced arthritisfarnesylthiosalicylic acidRas GTPasesrheumatoid arthritisT-helper cells

Identifiers

PMID28736556
PMCPMC5500629
OpenAlexW2732168157

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.