Evidence map›Paper›PMID 28736470›Full record

ArticleProceedings of SPIE--the International Society for Optical Engineering2017

Structural-Functional Relationships Between Eye Orbital Imaging Biomarkers and Clinical Visual Assessments.

Xiuya Yao, Shikha Chaganti, Kunal P Nabar, Katrina Nelson, Andrew Plassard, Rob L Harrigan, Louise A Mawn, Bennett A Landman

Abstract read
In one paragraph

Article in Proceedings of SPIE--the International Society for Optical Engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Contextual Deep Regression Network for Volume Estimation in Orbital CT.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2019
    Article
  2. Article
  3. EMR-Radiological Phenotypes in Diseases of the Optic Nerve and their Association with Visual Function.Deep learning in medical image analysis and multimodal learning for clinical decision support : Third International Workshop, DLMIA 2017, and 7th International Workshop, ML-CDS 2017, held in conjunction with MICCAI 2017 Quebec City, QC,... · 2017
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Xiuya YaoDepartment of Biomedical Informatics, Vanderbilt University, 2525 West End Ave #1475, Nashville, TN 37203.
Shikha ChagantiComputer Science, Vanderbilt University, 2301 Vanderbilt Place, Nashville, TN USA 37235.
Kunal P NabarComputer Science, Vanderbilt University, 2301 Vanderbilt Place, Nashville, TN USA 37235.
Katrina NelsonElectrical Engineering, Vanderbilt University, 2301 Vanderbilt Place, Nashville, TN USA 37235.
Andrew PlassardComputer Science, Vanderbilt University, 2301 Vanderbilt Place, Nashville, TN USA 37235.
Rob L HarriganElectrical Engineering, Vanderbilt University, 2301 Vanderbilt Place, Nashville, TN USA 37235.
Louise A MawnVanderbilt Eye Institute, Vanderbilt University School of Medicine, 2311 Pierce Avenue, Nashville, TN USA 37232.
Bennett A LandmanComputer Science, Vanderbilt University, 2301 Vanderbilt Place, Nashville, TN USA 37235.
Vanderbilt University · US

Funding

VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
BIDS: Vanderbilt Training Program in BIg Biomedical Data ScienceT32LM012412 · NLM · VANDERBILT UNIVERSITY · PI BLUME, JEFFREY D., GADD, CYNTHIA S · 2016 to 2020
$1.5M
Quantitative Image Analysis Techniques for Optic Nerve DiseaseR21EY024036 · NEI · VANDERBILT UNIVERSITY · PI LANDMAN, BENNETT A. · 2014 to 2015
$410k
NCATS NIH HHS UL1 TR000445NCRR NIH HHS UL1 RR024975NEI NIH HHS R21 EY024036NLM NIH HHS T32 LM012412
6 · The paper itself

Abstract

Eye diseases and visual impairment affect millions of Americans and induce billions of dollars in annual economic burdens. Expounding upon existing knowledge of eye diseases could lead to improved treatment and disease prevention. This research investigated the relationship between structural metrics of the eye orbit and visual function measurements in a cohort of 470 patients from a retrospective study of ophthalmology records for patients (with thyroid eye disease, orbital inflammation, optic nerve edema, glaucoma, intrinsic optic nerve disease), clinical imaging, and visual function assessments. Orbital magnetic resonance imaging (MRI) and computed tomography (CT) images were retrieved and labeled in 3D using multi-atlas label fusion. Based on the 3D structures, both traditional radiology measures (e.g., Barrett index, volumetric crowding index, optic nerve length) and novel volumetric metrics were computed. Using stepwise regression, the associations between structural metrics and visual field scores (visual acuity, functional acuity, visual field, functional field, and functional vision) were assessed. Across all models, the explained variance was reasonable (R2 ~ 0.1-0.2) but highly significant (p < 0.001). Instead of analyzing a specific pathology, this study aimed to analyze data across a variety of pathologies. This approach yielded a general model for the connection between orbital structural imaging biomarkers and visual function.

Indexed as

CTeyeMRImulti-atlasorbital structurevisual function

Identifiers

PMID28736470
PMCPMC5521276
OpenAlexW2592203356

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.