Evidence map›Paper›PMID 28736462›Full record

ArticleInternational journal of polymeric materials2017

Sequential Release of Multiple Drugs from Flexible Drug Delivery Films.

Cheryl L Jennings, Ellis K Perry, Thomas D Dziubla, David A Puleo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of polymeric materials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Cheryl L JenningsDepartment of Biomedical Engineering, University of Kentucky, Lexington, KY, USA.
Ellis K PerryDepartment of Biomedical Engineering, University of Kentucky, Lexington, KY, USA.
Thomas D DziublaDepartment of Chemical and Materials Engineering, University of Kentucky, Lexington, KY, USA.
David A PuleoDepartment of Biomedical Engineering, University of Kentucky, Lexington, KY, USA.

Funding

Modulating Inflammation and Fibrosis to Control Scarring in Muscle WoundsR01AR060964 · NIAMS · UNIVERSITY OF KENTUCKY · PI PULEO, DAVID A. · 2012 to 2015
$1.4M
Devices for Treating Inflammatory Bone Loss in an Oral EnvironmentR01DE019645 · NIDCR · UNIVERSITY OF KENTUCKY · PI PULEO, DAVID A. · 2009 to 2010
$801k
NIAMS NIH HHS R01 AR060964NIDCR NIH HHS R01 DE019645
6 · The paper itself

Abstract

Sequential release of drugs aligned with the phases of tissue healing could reduce scarring. To achieve this aim, layered film devices comprising cellulose acetate phthalate (CAP) and Pluronic F-127 (Pluronic) were loaded with ketoprofen, quercetin, and pirfenidone. Citrate plasticizers were added to impart flexibility. Release of two or three drugs in sequence over several days was obtained for all multilayered devices tested. Mechanical analysis showed that elongation increased and modulus decreased with increasing plasticizer content. Release profiles can be tailored by order of layers, plasticizer concentration, and drug loaded, making CAP-Pluronic an appealing system for inhibiting scar tissue formation.

Indexed as

cytotoxicity mechanical propertiesdrug deliveryplasticizerSequential drug release

Identifiers

PMID28736462
PMCPMC5515595

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.