ArticleInternational journal of obesity (2005)2017
Dietary fat and total energy intake modifies the association of genetic profile risk score on obesity: evidence from 48 170 UK Biobank participants.
Article in International journal of obesity (2005), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Polygenic Risk and Nutrient Intake Interactions on Obesity Outcomes: A Systematic Review and Meta-Analysis of Observational Studies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Pooled it
- In the context of the triple burden of malnutrition: A systematic review of gene-diet interactions and nutritional status.Critical reviews in food science and nutrition · 2024Pooled it
- Associations ofNutrients · 2019Pooled it
- Interactions Between Genetic Risk and Macronutrient Intake on Obesity-Related Traits in Sri Lankan Adults.Nutrients · 2026Article
- Interaction between a refined carbohydrate dietary pattern and genetic risk score for obesity in the Korean population.Public health nutrition · 2026Article
- Interaction of genetics risk score and fatty acids quality indices on healthy and unhealthy obesity phenotype.BMC medical genomics · 2025Article
- Relationships between the Planetary Health Diet Index, its food groups, and polygenic risk of obesity in the CARTaGENE cohort.Nutrition & metabolism · 2024Article
- How do lifestyle factors modify the association between genetic predisposition and obesity-related phenotypes? A 4-way decomposition analysis using UK Biobank.BMC medicine · 2024Article
- A genomics perspective of personalized prevention and management of obesity.Human genomics · 2024Review
- Precision Nutrition to Improve Risk Factors of Obesity and Type 2 Diabetes.Current nutrition reports · 2023Review
- Interactions Between Genetic Risk Score and Healthy Plant Diet Index on Cardiometabolic Risk Factors Among Obese and Overweight Women.Clinical nutrition research · 2023Article
- Precision Nutrition: Recent Advances in Obesity.Physiology (Bethesda, Md.) · 2023Review
- Associations of oxidative balance score with total abdominal fat mass and visceral adipose tissue mass percentages among young and middle-aged adults: findings from NHANES 2011-2018.Frontiers in nutrition · 2023Article
- Dietary Mediators of the Genetic Susceptibility to Obesity-Results from the Quebec Family Study.The Journal of nutrition · 2022Article
- Differential response to a 6-month energy-restricted treatment depending on SH2B1 rs7359397 variant in NAFLD subjects: Fatty Liver in Obesity (FLiO) Study.European journal of nutrition · 2021Article
- Healthful plant-based dietary patterns, genetic risk of obesity, and cardiovascular risk in the UK biobank study.Clinical nutrition (Edinburgh, Scotland) · 2021Article
- Three Different Genetic Risk Scores Based on Fatty Liver Index, Magnetic Resonance Imaging and Lipidomic for a Nutrigenetic Personalized Management of NAFLD: The Fatty Liver in Obesity Study.Diagnostics (Basel, Switzerland) · 2021Article
- An automatic electronic instrument for accurate measurements of food volume and density.Public health nutrition · 2021Article
- Interaction between the genetic risk score and dietary protein intake on cardiometabolic traits in Southeast Asian.Genes & nutrition · 2020Article
- Interaction between Metabolic Genetic Risk Score and Dietary Fatty Acid Intake on Central Obesity in a Ghanaian Population.Nutrients · 2020Article
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
Abstract
backgroundObesity is a multifactorial condition influenced by both genetics and lifestyle. The aim of this study was to investigate whether the association between a validated genetic profile risk score for obesity (GPRS-obesity) and body mass index (BMI) or waist circumference (WC) was modified by macronutrient intake in a large general population study.
methodsThis study included cross-sectional data from 48 170 white European adults, aged 37-73 years, participating in the UK Biobank. Interactions between GPRS-obesity and macronutrient intake (including total energy, protein, fat, carbohydrate and dietary fibre intake) and its effects on BMI and WC were investigated.
resultsThe 93-single-nucleotide polymorphism (SNP) GPRS was associated with a higher BMI (β: 0.57 kg m
conclusionsThese data suggest that the benefits of reducing the intake of fats and total energy intake may be more important in individuals with high genetic risk for obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.