ReviewThe ocular surface2017
TFOS DEWS II Tear Film Report.
Review in The ocular surface, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04198740 (Proteomic and Metabolomic Lacrimal Fingerprint in Diverse Pathologies of the Ocular Surface), which is not on this map. Cited by 439 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Proteomic and Metabolomic Lacrimal Fingerprint in Diverse Pathologies of the Ocular Surface
Who cites it
439 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Assessing the therapeutic role of trehalose and hyaluronic acid: implications for patient care.International ophthalmology · 2024Pooled it
- Autologous serum eye drops for patients with dry eye disease: a systematic review and meta-analysis of randomized controlled trials.Frontiers in medicine · 2024Pooled it
- Efficacy and safety of a multi-action tear substitute based on 0.15% cross-linked hyaluronic acid, 3% trehalose and liposomes with stearylamine: A randomized, single-mask, controlled study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Trial
- Effect of laughter exercise versus 0.1% sodium hyaluronic acid on ocular surface discomfort in dry eye disease: non-inferiority randomised controlled trial.BMJ (Clinical research ed.) · 2024Trial
- Comparing automated and manual assessments of tear break-up time using different non-invasive devices and a fluorescein procedure.Scientific reports · 2024Trial
- The Significance of Dry Eye Signs on Preoperative Keratometry Measurements in Patients Scheduled for Cataract Surgery.Clinical ophthalmology (Auckland, N.Z.) · 2024Trial
- Effect of Artificial Tears on Preoperative Keratometry and Refractive Precision in Cataract Surgery.Clinical ophthalmology (Auckland, N.Z.) · 2024Trial
- Effect of a single warm compress prior to ophthalmic surgery on ocular surface and intraoperative visibility: a randomised controlled study.BMJ open ophthalmology · 2023Trial
- Functional and morphological evaluation of the meibomian glands and ocular surface assessment at high altitude.Indian journal of ophthalmology · 2023Trial
- Comparative evaluation of effectiveness of twenty versus fifty percent autologous serum eye drops in treatment of dry eye.Indian journal of ophthalmology · 2023Trial
- Site-specific O-glycans influence lacritin structure and multimerization in tears.Protein science : a publication of the Protein Society · 2026Article
- Infraorbital Skin Application of Menthol Emulsion for Dry Eye Disease: A Randomized Clinical Trial.Ophthalmology and therapy · 2026Article
- Article
- Benchmarking Statistical, Machine Learning, and Exploratory Deep Learning Models for the Short-Term Forecasting of Monthly Aggregated Adult Ocular Surface Indicators: An Exploratory Hospital-Level Study.Diagnostics (Basel, Switzerland) · 2026Article
- Reference Estimates of Mean Tear Film Lipid Layer Thickness Measured with LipiViewJournal of clinical medicine · 2026Review
- Canine Tear Proteomics: A New Frontier in Veterinary Ophthalmology.Veterinary ophthalmology · 2026Review
- Electroacupuncture promotes the repair of lacrimal glands damage in dry-eye animal models by modulating the BDNF/CREB signaling pathway.Journal of traditional and complementary medicine · 2026Article
- Measurement of Anions in Dog Tear Fluid Using Ion Chromatography.Veterinary ophthalmology · 2026Article
- Liposomal Drug Delivery in Ocular Therapy: Strategies for Enhancing Corneal Penetration and Bioavailability.Cells · 2026Review
- Eyelid and tear-film factors associated with contact lens discomfort symptom burden among wearers attending after-care in Kisumu County, Kenya: a clinic-based cross-sectional study.BMC ophthalmology · 2026Article
379 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
The members of the Tear Film Subcommittee reviewed the role of the tear film in dry eye disease (DED). The Subcommittee reviewed biophysical and biochemical aspects of tears and how these change in DED. Clinically, DED is characterized by loss of tear volume, more rapid breakup of the tear film and increased evaporation of tears from the ocular surface. The tear film is composed of many substances including lipids, proteins, mucins and electrolytes. All of these contribute to the integrity of the tear film but exactly how they interact is still an area of active research. Tear film osmolarity increases in DED. Changes to other components such as proteins and mucins can be used as biomarkers for DED. The Subcommittee recommended areas for future research to advance our understanding of the tear film and how this changes with DED. The final report was written after review by all Subcommittee members and the entire TFOS DEWS II membership.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.