Evidence map›Paper›PMID 28736316›Full record

ArticleThe American journal of pathology2017

Early Actions of Anti-Vascular Endothelial Growth Factor/Vascular Endothelial Growth Factor Receptor Drugs on Angiogenic Blood Vessels.

Basel Sitohy, Sunghee Chang, Tracey E Sciuto, Elizabeth Masse, Mei Shen, Peter M Kang, Shou-Ching Jaminet, Laura E Benjamin, Rupal S Bhatt, Ann M Dvorak and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in The American journal of pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 35 citations in OpenAlex.

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  15. The Effect of Terpenoid Natural Chinese Medicine Molecular Compound on Lung Cancer Treatment.Evidence-based complementary and alternative medicine : eCAM · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Basel SitohyThe Center for Vascular Biology Research and the Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Sunghee ChangThe Center for Vascular Biology Research and the Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Tracey E SciutoThe Center for Vascular Biology Research and the Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Elizabeth MasseThe Center for Vascular Biology Research and the Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Mei ShenThe Center for Vascular Biology Research and the Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Peter M KangDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Shou-Ching JaminetThe Center for Vascular Biology Research and the Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Laura E BenjaminThe Center for Vascular Biology Research and the Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Rupal S BhattDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Ann M DvorakThe Center for Vascular Biology Research and the Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Janice A NagyThe Center for Vascular Biology Research and the Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Harold F DvorakThe Center for Vascular Biology Research and the Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts. Electronic address: hdvorak@bidmc.harvard.edu.
Harvard University · USBeth Israel Deaconess Medical Center · USCenter for Vascular Biology Research · US

Funding

The Role of PlGF in Normal and Neoplastic AngiogenesisP01CA092644 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI DVORAK, HAROLD FISHER · 2002 to 2013
$17.2M
Combating Resistance to Antiangiogenic Therapy in Renal Cell CarcinomaR01CA196996 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BHATT, RUPAL S · 2015 to 2019
$2.0M
NCI NIH HHS P01 CA092644NCI NIH HHS R01 CA196996
6 · The paper itself

Abstract

Tumors induce their heterogeneous vasculature by secreting vascular endothelial growth factor (VEGF)-A. Anti-VEGF/VEGF receptor (VEGFR) drugs treat cancer, but the underlying mechanisms remain unclear. An adenovirus expressing VEGF-A (Ad-VEGF-A

Indexed as

AdenoviridaeAngiogenesis InhibitorsAnimalsBibenzylsBlood VesselsCell DeathCell ProliferationEndothelial CellsFemaleHypertensionMice, Inbred C57BLMice, NudeMicrovesselsModels, BiologicalNeovascularization, PhysiologicNG-Nitroarginine Methyl EsterafliberceptAngiogenesis InhibitorsBibenzylscombretastatinNG-Nitroarginine Methyl EsterNitric Oxide Synthase Type IIIReceptors, Vascular Endothelial Growth FactorRecombinant Fusion ProteinsVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-2

Identifiers

PMID28736316
PMCPMC5809587
OpenAlexW2739305418

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.