ReviewNeuroImage2019
Laminar fMRI: What can the time domain tell us?
Review in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed.
- A synthetic 3D human cerebrovascular model informed by histology for simulating the cortical depth-dependent BOLD fMRI signal.PLoS computational biology · 2026Article
- Large gains in SNR through the application of Shinnar-Le Roux RF pulse design to short-TR spin-echo fMRI acquisitions at 7 T.Magnetic resonance imaging · 2026Article
- Article
- Layer-specific BOLD effects in gradient and spin-echo acquisitions in somatosensory cortex.Magnetic resonance in medicine · 2025Article
- Real-time fMRI using multi-band echo-volumar imaging with millimeter spatial resolution and sub-second temporal resolution at 3 tesla.Frontiers in neuroscience · 2025Article
- Impact of vascular architecture, oxygen saturation, and hematocrit on human cortical depth-dependent GE- and SE-BOLD fMRI signals: A simulation approach using realistic 3D vascular networks.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Unresponsiveness induced by sevoflurane and propofol is associated with reduced basal forebrain cholinergic nuclei functional connectivity in humans,Neuroimage. Reports · 2024Article
- The contribution of the vascular architecture and cerebrovascular reactivity to the BOLD signal formation across cortical depth.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- A fully synthetic three-dimensional human cerebrovascular model based on histological characteristics to investigate the hemodynamic fingerprint of the layer BOLD fMRI signal formation.bioRxiv : the preprint server for biology · 2024Article
- A selection and targeting framework of cortical locations for line-scanning fMRI.Human brain mapping · 2023Article
- The nature and neurobiology of fear and anxiety: State of the science and opportunities for accelerating discovery.Neuroscience and biobehavioral reviews · 2023Review
- A vision of 14 T MR for fundamental and clinical science.Magma (New York, N.Y.) · 2023Review
- Modelling the depth-dependent VASO and BOLD responses in human primary visual cortex.Human brain mapping · 2023Article
- Cortical depth-dependent human fMRI of resting-state networks using EPIK.Frontiers in neuroscience · 2023Article
- Do sparse brain activity patterns underlie human cognition?NeuroImage · 2022Article
- Statistical power or more precise insights into neuro-temporal dynamics? Assessing the benefits of rapid temporal sampling in fMRI.Progress in neurobiology · 2021Review
- Imaging faster neural dynamics with fast fMRI: A need for updated models of the hemodynamic response.Progress in neurobiology · 2021Review
- Linking cortical circuit models to human cognition with laminar fMRI.Neuroscience and biobehavioral reviews · 2021Review
- LayNii: A software suite for layer-fMRI.NeuroImage · 2021Article
- Point-spread function of the BOLD response across columns and cortical depth in human extra-striate cortex.Progress in neurobiology · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The rapid developments in functional MRI (fMRI) acquisition methods and hardware technologies in recent years, particularly at high field (≥7 T), have enabled unparalleled visualization of functional detail at a laminar or columnar level, bringing fMRI close to the intrinsic resolution of brain function. These advances highlight the potential of high resolution fMRI to be a valuable tool to study the fundamental processing performed in cortical micro-circuits, and their interactions such as feedforward and feedback processes. Notably, because fMRI measures neuronal activity via hemodynamics, the ultimate resolution it affords depends on the spatial specificity of hemodynamics to neuronal activity at a detailed spatial scale, and by the evolution of this specificity over time. Several laminar (≤1 mm spatial resolution) fMRI studies have examined spatial characteristics of the measured hemodynamic signals across cortical depth, in light of understanding or improving the spatial specificity of laminar fMRI. Few studies have examined temporal features of the hemodynamic response across cortical depth. Temporal features of the hemodynamic response offer an additional means to improve the specificity of fMRI, and could help target neuronal processes and neurovascular coupling relationships across laminae, for example by differences in the onset times of the response across cortical depth. In this review, we discuss factors that affect the timing of neuronal and hemodynamic responses across laminae, touching on the neuronal laminar organization, and focusing on the laminar vascular organization. We provide an overview of hemodynamics across the cortical vascular tree based on optical imaging studies, and review temporal aspects of hemodynamics that have been examined across cortical depth in high spatiotemporal resolution fMRI studies. Last, we discuss the limits and potential of high spatiotemporal resolution fMRI to study laminar neurovascular coupling and neuronal processes.
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