ArticleCurrent biology : CB2017
Overlap among Spatial Memories Triggers Repulsion of Hippocampal Representations.
Article in Current biology : CB, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers.
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Who cites it
103 citing papers in PubMed.
- Hippocampal Mechanisms Support Cortisol-Induced Memory Enhancements.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Trial
- Reductions in Retrieval Competition Predict the Benefit of Repeated Testing.Scientific reports · 2018Trial
- A population code for semantics in human hippocampus.Nature neuroscience · 2026Article
- Context-dependent abstraction of temporal relationships during naturalistic episodic memory.iScience · 2026Article
- Hippocampal mechanisms underlying the resolution of competition in memory and perception.Nature communications · 2026Article
- Generalisation between motor and declarative memory sequences: A conceptual replication of Mosha & Robertson (2016).iScience · 2026Article
- Spontaneous emergence of context-dependent statistical learning in humans and neural networks.iScience · 2026Article
- The hippocampus rapidly integrates sequence representations during novel multistep predictions.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Article
- Children and adults use distinct neurocognitive mechanisms to support successful memory-based inference.bioRxiv : the preprint server for biology · 2026Article
- Medial temporal lobe encodes cognitive maps of real-world social networks.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Hippocampal patterns and associative memory: Distinct intracranial EEG temporal encoding patterns support memory.bioRxiv : the preprint server for biology · 2026Article
- Differential representations of spatial environments in mPFC and hippocampus underpinning flexible navigation.NeuroImage · 2026Article
- Safety-relevant experience reshapes neural codes for ambiguous threat in adolescents.Social cognitive and affective neuroscience · 2026Article
- The Role of Rapid Eye Movement Sleep in Neural Differentiation of Memories in the Hippocampus.Journal of cognitive neuroscience · 2026Article
- A Toaster in the Bathroom: Neural Correlates of Semantic Construction During Episodic Memory Recall.Human brain mapping · 2025Article
- High coherence among training exemplars promotes broad generalization of face families.Journal of experimental psychology. Learning, memory, and cognition · 2025Article
- Hippocampal transformations occur along dimensions of memory interference.bioRxiv : the preprint server for biology · 2025Article
- A compressed code for memory discrimination.bioRxiv : the preprint server for biology · 2025Article
- The Hippocampus Rapidly Integrates Sequence Representations During Novel Multistep Predictions.bioRxiv : the preprint server for biology · 2025Article
- Maintenance suppression enhances subsequent associative learning.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
43 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
Abstract
Across the domains of spatial navigation and episodic memory, the hippocampus is thought to play a critical role in disambiguating (pattern separating) representations of overlapping events. However, it is not fully understood how and why hippocampal patterns become separated. Here, we test the idea that event overlap triggers a "repulsion" among hippocampal representations that develops over the course of learning. Using a naturalistic route-learning paradigm and spatiotemporal pattern analysis of human fMRI data, we found that hippocampal representations of overlapping routes gradually diverged with learning to the point that they became less similar than representations of non-overlapping events. In other words, the hippocampus not only disambiguated overlapping events but formed representations that "reversed" the objective similarity among routes. This finding, which was selective to the hippocampus, is not predicted by standard theoretical accounts of pattern separation. Critically, because the overlapping route stimuli that we used ultimately diverged (so that each route contained overlapping and non-overlapping segments), we were able to test whether the reversal effect was selective to the overlapping segments. Indeed, once overlapping routes diverged (eliminating spatial and visual similarity), hippocampal representations paradoxically became relatively more similar. Finally, using a novel analysis approach, we show that the degree to which individual hippocampal voxels were initially shared across route representations was predictive of the magnitude of learning-related separation. Collectively, these findings indicate that event overlap triggers a repulsion of hippocampal representations-a finding that provides critical mechanistic insight into how and why hippocampal representations become separated.
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Registered trials
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