ArticleJournal of the American Society of Echocardiography : official publication of the American Society of Echocardiography2017
Clinical and Echocardiographic Correlates of Left Atrial Function Index: The Framingham Offspring Study.
Article in Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Effect of glycemic status on the natural history of left atrial structure and function in adults with metabolic syndrome and obesity.International journal of cardiology · 2026Observational
- Article
- Novel predictive role of glomerular filtration rate in atrial fibrillation development among chronic heart failure patients.BMC cardiovascular disorders · 2025Article
- Brady- and tachyarrhythmias detected by continuous rhythm monitoring in paroxysmal atrial fibrillation.Heart (British Cardiac Society) · 2023Observational
- Left atrial function index predicts poor outcome in STEMI patients treated with percutaneous coronary intervention.Scientific reports · 2023Article
- Article
- Stroke in mitral valve prolapse: risk factors and left atrial function in cryptogenic versus non-cryptogenic ischemic subtypes.Frontiers in neurology · 2023Article
- The association of left ventricular fraction shortening with cardiovascular events in peritoneal dialysis patients.Renal failure · 2023Observational
- Left atrial function index predicts poor outcomes in acute myocardial infarction patients treated with percutaneous coronary intervention.Frontiers in cardiovascular medicine · 2023Article
- Article
- Association of lung diffusion capacity with cardiac remodeling and risk of heart failure: The Framingham heart study.PloS one · 2021Article
- Pathophysiology of Hypertensive Heart Disease: Beyond Left Ventricular Hypertrophy.Current hypertension reports · 2020Review
- Prognostic Significance of Echocardiographic Measures of Cardiac Remodeling.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2020Article
- Association of subclinical atherosclerosis with echocardiographic indices of cardiac remodeling: The Framingham Study.PloS one · 2020Article
- Article
- Article
- Association of Circulating Ceramides With Cardiac Structure and Function in the Community: The Framingham Heart Study.Journal of the American Heart Association · 2019Article
- Association of Left Atrial Function Index with Atrial Fibrillation and Cardiovascular Disease: The Framingham Offspring Study.Journal of the American Heart Association · 2018Article
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Authors and funding
16 authors.
Funding
Abstract
backgroundLeft atrial (LA) remodeling is a predictor of cardiovascular disease (CVD). We performed measurement of the LA function index (LAFI), a composite measure of LA structure and function, in a community-based cohort and here report the distribution and cross-sectional correlates of LAFI.
methodsIn 1,719 Framingham Offspring Study participants (54% women, mean age 66 ± 9 years), we derived LAFI from the LA emptying fraction, left ventricular (LV) outflow tract velocity time integral, and indexed maximal LA volume. We used multivariable linear regression to assess the clinical and echocardiographic correlates of LAFI adjusting for age, sex, anthropometric measurements, and CVD risk factors.
resultsThe average LAFI was 35.2 ± 12.1. Overall, LAFI declined with advancing age (β = -0.27, P < .001). LAFI was significantly higher (37.5 ± 11.6) in a subgroup of participants free of CVD and CVD risk factors compared with those with either of these conditions (34.5 ± 12.2). In multivariable models, LAFI was inversely related to antihypertensive use (β = -1.26, P = .038), prevalent atrial fibrillation (β = -4.46, P = .001), heart failure (β = -5.86, P = .008), and coronary artery disease (β = -2.01, P = .046). In models adjusting for echocardiographic variables, LAFI was directly related to LV ejection fraction (β = 14.84, P < .001) and inversely related to LV volume (β = -7.03, P < .001).
conclusionsLAFI was inversely associated with antihypertensive use and prevalent CVD and was related to established echocardiographic traits of LV remodeling. Our results offer normative ranges for LAFI in a white community-based sample and suggest that LAFI represents a marker of pathological atrial remodeling.
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