ArticlePublic health nutrition2017
Independent associations of dairy and calcium intakes with colorectal cancers in the Adventist Health Study-2 cohort.
Article in Public health nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Cheese consumption and multiple health outcomes: an umbrella review and updated meta-analysis of prospective studies.Advances in nutrition (Bethesda, Md.) · 2023Pooled it
- Pooled it
- Hexanoic Acid Intake Enhances Anti-Tumor Immune Responses in Colorectal Cancer by Reducing the Immunosuppressive Function of Tregs.Molecular nutrition & food research · 2025Article
- Longitudinal associations between vegetarian dietary habits and site-specific cancers in the Adventist Health Study-2 North American cohort.The American journal of clinical nutrition · 2025Article
- Associations of intakes of total protein, protein from dairy sources, and dietary calcium with risks of colorectal, breast, and prostate cancer: a prospective analysis in UK Biobank.British journal of cancer · 2023Article
- Dairy foods, calcium intakes, and risk of incident prostate cancer in Adventist Health Study-2.The American journal of clinical nutrition · 2022Article
- Ultra-processed food intake and animal-based food intake and mortality in the Adventist Health Study-2.The American journal of clinical nutrition · 2022Observational
- Perspectives from healthcare professionals on the nutritional adequacy of plant-based dairy alternatives: results of a mixed methods inquiry.BMC nutrition · 2022Article
- Milk consumption and multiple health outcomes: umbrella review of systematic reviews and meta-analyses in humans.Nutrition & metabolism · 2021Review
- Adherence to the Recommended Intake of Calcium and Colorectal Cancer Risk in the HEXA Study.Cancer research and treatment · 2021Article
- Are long-term FAD diets restricting micronutrient intake? A randomized controlled trial.Food science & nutrition · 2020Article
- Vegetarian Epidemiology: Review and Discussion of Findings from Geographically Diverse Cohorts.Advances in nutrition (Bethesda, Md.) · 2019Review
- High lactose whey cheese consumption and risk of colorectal cancer - The Norwegian Women and Cancer Study.Scientific reports · 2019Article
- Do dietary calcium and vitamin D matter in men with prostate cancer?Nature reviews. Urology · 2018Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveResults associating dairy and Ca intakes with colorectal cancer (CRC) risk have been mixed. Most previous analyses have suffered from confounding between dairy and Ca intakes. We examined independent associations between these variables, also dairy foods, and CRC incidence in a population with a large range of dairy intakes.
designAdventist Health Study-2 is a cohort study where subjects were enrolled 2002-2007. Proportional hazard regression analyses were performed to estimate hazard ratios (HR). Regression calibration was used to correct for dietary measurement error.
settingThe population lived in all states of the USA. SUBJECTS: There were 77712 analytic subjects, all of whom were Seventh-day Adventists. Much of their dietary Ca came from non-dairy sources. SUBJECTS: During a mean follow-up of 7·8 years, 380 incident colon cancer and 111 incident rectal cancer cases were observed.
resultsComparing extreme quintiles of intake in measurement error-corrected analyses, dairy intake (HR=0·31; 95 % CI 0·09, 0·88), independent of total Ca, was inversely related with risk of rectal cancer but gave little indication of association with colon cancer. However, total Ca intake (independent of dairy) was associated with risk of colon cancer (HR=0·55; 95 % CI 0·28, 0·98) and there was little indication of association with rectal cancer. Traditional regression analyses and associations with macronutrients from dairy generally supported these results. Milk intake was also negatively associated with CRC (HR=0·63; 95 % CI 0·43, 0·89).
conclusionsDairy intake may decrease the risk of rectal cancer, and Ca may reduce risk of colon cancer and CRC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.