ArticleInternational journal of colorectal disease2017
Risk factors associated with postoperative recurrence and repeat surgery in Japanese patients with Crohn's disease.
Article in International journal of colorectal disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Incidence, risk factors and preventive strategies for post-operative recurrence of Crohn's disease: A retrospective propensity-matched cohort analysis.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Article
- A retrospective, observational study to examine the effect of early tumor necrosis factor inhibitor use on rates of surgery for Crohn's disease in Japan.BMC gastroenterology · 2025Observational
- Perianal fistulizing lesions of Crohn's disease are associated with long-term behavior and its transition: a Chinese cohort study.Intestinal research · 2024Article
- Review
- Retrospective Study of Surgical Outcomes in 60 Patients with Crohn Disease from a Single Center in Poland.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- Capsule Endoscopy Is Useful for Postoperative Tight Control Management in Patients with Crohn's Disease.Digestive diseases and sciences · 2022Article
- Elemental diet therapy plays a significant role in preventing surgical recurrence of Crohn's disease in the era of biologics.Surgery today · 2021Article
- Risk Factors for Postoperative Recurrence in Korean Patients with Crohn's Disease.Gut and liver · 2020Article
- No Association between staging operation and the 5-Year Risk of Reoperation in Patients with Crohn's Disease.Scientific reports · 2019Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo avoid frequent surgery in patients with Crohn's disease, it is important to identify the risk factors for postoperative recurrence or repeat surgery. However, there have so far been few studies on this topic from Asian countries. In addition, the recent development of anti-tumor necrosis factor (TNF) therapy may have changed the risk factors. We aimed to identify the factors associated with postoperative recurrence and repeat surgery.
methodsThe postoperative courses of 168 patients were reviewed. We analyzed the cumulative postoperative recurrence and repeat surgery rates and identified the factors affecting these rates.
resultsPostoperative recurrence was observed in 70 patients, and the 1-, 3-, and 5-year cumulative recurrence rates were 17.1, 40.1, and 54.9%, respectively. The recurrence rate was significantly higher in patients with anal lesions and lower in patients newly treated with anti-TNF agents following surgery. In a multivariate analysis, the new introduction of anti-TNF agents was identified as an independent suppressor (hazard ratio 0.50, 95% confidence interval 0.28-0.88). Twenty-four patients underwent repeat surgery, and the 1-, 3-, and 5-year cumulative repeat surgery rates were 4.6, 11.2, and 18.7%, respectively. The surgery rate was significantly higher in patients with penetrating-type disease. In a multivariate analysis, penetrating-type disease (6.98, 2.37-23.35), anal lesions (4.40, 1.14-30.53), and first-time surgery (5.28, 1.17-17.93) were identified as independent risk factors.
conclusionsAnti-TNF agents have the potential to prevent postoperative recurrence. The new introduction, dose escalation, or switching of anti-TNF agents is recommended in patients with some risk factors.
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