ArticleAddictive behaviors2018
Frequency and correlates of sleep disturbance in methadone and buprenorphine-maintained patients.
Article in Addictive behaviors, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Behavioral Intervention to Improve Insomnia Symptoms in Patients With Opioid Use Disorder
Pomegranate Juice Consumption by Patients Under Medication for Addiction Treatment as a Regulator of Craving and Blood Redox Status: The Study Protocol of a Randomized Control Trial (the NUTRIDOPE Study)
Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prevalence of sleep-related symptoms in patients receiving methadone maintenance treatment: a systematic review and meta-analysis.Addiction science & clinical practice · 2026Pooled it
- Sleep Health Among Adults in Outpatient Opioid Use Disorder Treatment: A Systematic Review.Journal of psychosocial nursing and mental health services · 2024Pooled it
- Effectiveness of Conditioned Open-label Placebo With Methadone in Treatment of Opioid Use Disorder: A Randomized Clinical Trial.JAMA network open · 2023Trial
- Sleep reductions associated with illicit opioid use and clinic-hour changes during opioid agonist treatment for opioid dependence: Measurement by electronic diary and actigraphy.Journal of substance abuse treatment · 2019Trial
- Latent classes of sleep deficiency and correlates among patients receiving methadone treatment: A longitudinal study.Addiction (Abingdon, England) · 2026Article
- Blunted light exposure amplitudes in patients with opioid use disorder.Npj biological timing and sleep · 2026Article
- Nighttime Sleep Symptoms and Sleep-Relevant Medication Documentation Among Adults Receiving Buprenorphine for Opioid Use Disorder.Substance abuse and rehabilitation · 2026Article
- Article
- Naltrexone blocks the sleep-disrupting effects of methamphetamine in male rhesus monkeys.Drug and alcohol dependence · 2025Article
- Article
- Phase 1b/2a safety study of lemborexant as an adjunctive treatment for insomnia to buprenorphine-naloxone for opioid use disorder: A randomized controlled trial.Drug and alcohol dependence reports · 2025Article
- Rest-Activity Rhythms, Their Modulators, and Brain-Clinical Correlates in Opioid Use Disorder.JAMA network open · 2025Article
- Spontaneous oxycodone withdrawal disrupts sleep, diurnal, and electrophysiological dynamics in rats.PloS one · 2025Article
- Associations Among Sleep, Pain, and Medications for Opioid Use Disorder: a Scoping Review.Current addiction reports · 2024Article
- Alternative Reinforcers Enhance the Effects of Opioid Antagonists, but Not Agonists, on Oxycodone Choice Self-Administration in Nonhuman Primates.The Journal of pharmacology and experimental therapeutics · 2024Article
- Enhancing translation: A need to leverage complex preclinical models of addictive drugs to accelerate substance use treatment options.Pharmacology, biochemistry, and behavior · 2024Review
- Disrupted Circadian Rhythms and Substance Use Disorders: A Narrative Review.Clocks & sleep · 2024Review
- Pain and withdrawal are common among patients receiving medications for opioid use disorder and associated with pain catastrophizing, negative affect, and poor sleep.Experimental and clinical psychopharmacology · 2024Article
- Pharmacologic profile of ITI-333: a novel molecule for treatment of substance use disorders.Psychopharmacology · 2024Article
- Biological sex influences sleep phenotype in mice experiencing spontaneous opioid withdrawal.Journal of sleep research · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundOpioid use disorder (OUD) is a significant public health problem, and opioid maintenance treatment (OMT) on methadone or buprenorphine is a common approach. This study characterized sleep impairment in patients maintained on methadone or buprenorphine, and evaluated its association with psychiatric and medical comorbidities.
methodsParticipants (N=185) maintained on methadone (N=125) or buprenorphine (N=60) for OUD completed the Medical Outcomes Study Sleep Scale (MOS) to provide a point-prevalence assessment of sleep impairment. Measures of lifetime problems and current functioning were also examined and compared as both a function of OMT and level of sleep impairment.
resultsParticipants reported high levels of sleep impairment on the MOS, including not getting the amount of sleep they needed (42.9%), not sleeping enough to feel rested (39.6%) and trouble falling asleep (23.3%) or falling back asleep after waking (25.8%). Few differences were observed between OMT groups, and psychiatric dysfunction emerged as the most robust predictor of sleep impairment ratings. Patients with sleep impairment, independent of OMT medications, also reported current opioid withdrawal, psychiatric impairment, negative affect, and pain.
conclusionsResults demonstrate substantial and clinically-significant impairments in sleep that are associated with a variety of current problems that could impact OMT outcomes and decrease quality of life. Outcomes support the development of methods to improve sleep in OMT patients, and to examine the degree to which sleep improvements may be associated with improvements in mood and other health-related measures.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.