Evidence map›Paper›PMID 28734899›Full record

ReviewAdvanced drug delivery reviews2017

Strategies to develop endogenous stem cell-recruiting bioactive materials for tissue repair and regeneration.

Settimio Pacelli, Sayantani Basu, Jonathan Whitlow, Aparna Chakravarti, Francisca Acosta, Arushi Varshney, Saman Modaresi, Cory Berkland, Arghya Paul

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advanced drug delivery reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed.

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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Settimio PacelliDepartment of Chemical and Petroleum Engineering, Bioengineering Graduate Program, University of Kansas, Lawrence, KS, USA. Electronic address: sepace@ku.edu.
Sayantani BasuDepartment of Chemical and Petroleum Engineering, Bioengineering Graduate Program, University of Kansas, Lawrence, KS, USA. Electronic address: sayantani.basu@ku.edu.
Jonathan WhitlowDepartment of Chemical and Petroleum Engineering, Bioengineering Graduate Program, University of Kansas, Lawrence, KS, USA. Electronic address: jww@ku.edu.
Aparna ChakravartiDepartment of Chemical and Petroleum Engineering, Bioengineering Graduate Program, University of Kansas, Lawrence, KS, USA. Electronic address: aparnach@ku.edu.
Francisca AcostaDepartment of Chemical and Petroleum Engineering, Bioengineering Graduate Program, University of Kansas, Lawrence, KS, USA. Electronic address: francisca.acosta@utsa.edu.
Arushi VarshneyDepartment of Human Genetics, University of Michigan, Ann Arbor, MI, USA. Electronic address: arushiv@umich.edu.
Saman ModaresiDepartment of Chemical and Petroleum Engineering, Bioengineering Graduate Program, University of Kansas, Lawrence, KS, USA. Electronic address: saman.modaresi@ku.edu.
Cory BerklandDepartment of Chemical and Petroleum Engineering, Bioengineering Graduate Program, University of Kansas, Lawrence, KS, USA; Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS, USA. Electronic address: berkland@ku.edu.
Arghya PaulDepartment of Chemical and Petroleum Engineering, Bioengineering Graduate Program, University of Kansas, Lawrence, KS, USA. Electronic address: arghyapaul@ku.edu.

Funding

Understanding the mechanobiology of stem cells in a microengineered 3D cardiac tissue environment with cardiomyopathyP20GM103638 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI LUNTE, SUSAN M · 2012 to 2021
$22.1M
KU Post-Baccalaureate Research Education Program (PREP)R25GM078441 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI V GUSTAVO BLANCO, Paulyn Cartwright · 2006 to 2026
$6.6M
NIGMS NIH HHS P20 GM103638NIGMS NIH HHS R25 GM078441
6 · The paper itself

Abstract

A leading strategy in tissue engineering is the design of biomimetic scaffolds that stimulate the body's repair mechanisms through the recruitment of endogenous stem cells to sites of injury. Approaches that employ the use of chemoattractant gradients to guide tissue regeneration without external cell sources are favored over traditional cell-based therapies that have limited potential for clinical translation. Following this concept, bioactive scaffolds can be engineered to provide a temporally and spatially controlled release of biological cues, with the possibility to mimic the complex signaling patterns of endogenous tissue regeneration. Another effective way to regulate stem cell activity is to leverage the inherent chemotactic properties of extracellular matrix (ECM)-based materials to build versatile cell-instructive platforms. This review introduces the concept of endogenous stem cell recruitment, and provides a comprehensive overview of the strategies available to achieve effective cardiovascular and bone tissue regeneration.

Indexed as

AnimalsBone RegenerationChemotactic FactorsGuided Tissue RegenerationHumansStem CellsChemotactic FactorsBone graft substitutesChemoattractant gradientsEndothelializationExtracellular matrixGrowth factor deliveryMyocardial regenerationStem cell homing

Identifiers

PMID28734899
PMCPMC5705585

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.