Evidence map›Paper›PMID 28734867›Full record

ArticleNeuropharmacology2017

P/Q-type voltage-gated calcium channels mediate the ethanol and CRF sensitivity of central amygdala GABAergic synapses.

F P Varodayan, M L Logrip, M Roberto

Abstract read
In one paragraph

Article in Neuropharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Synaptic Effects Induced by Alcohol.Current topics in behavioral neurosciences · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Synaptic effects of IL-1β and CRF in the central amygdala after protracted alcohol abstinence in male rhesus macaques.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Article
  10. Article
  11. Article
  12. The Role of the Central Amygdala in Alcohol Dependence.Cold Spring Harbor perspectives in medicine · 2021
    Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Opposing actions of CRF-R1 and CB1 receptors on VTA-GABAergic plasticity following chronic exposure to ethanol.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

F P VarodayanThe Scripps Research Institute, Department of Neuroscience, La Jolla, CA 92037, USA. Electronic address: varodaya@scripps.edu.
M L LogripThe Scripps Research Institute, Department of Neuroscience, La Jolla, CA 92037, USA.
M RobertoThe Scripps Research Institute, Department of Neuroscience, La Jolla, CA 92037, USA.
Scripps Research Institute · US

Funding

Viral Vector CoreP60AA006420 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARISA ROBERTO · 2003 to 2026
$46.3M
Electrophysiology of alcohol in extended amygdelaU01AA013498 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARISA ROBERTO · 2001 to 2026
$12.6M
SYSTEMIC NEUROPHARMACOLOGYP50AA006420 · NIAAA · SCRIPPS RESEARCH INSTITUTE · PI RIVIER, CATHERINE L · 1985 to 2002
$5.1M
Regulation of Ethanol Effects on Synaptic TransmissionR01AA015566 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2006 to 2019
$4.6M
Neuroplasticity of the Extended Amygdala CRF circuitry in alcohol dependenceR01AA021491 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2013 to 2024
$3.9M
Gene-environment interaction: the brain CRF system in alcohol preferring msP ratsR37AA017447 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2016 to 2025
$3.7M
Gene-environment interaction: the brain CRF system in alcohol preferring msP ratsR01AA017447 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2009 to 2013
$1.8M
Sex differences in stress-alcohol interactions modulating amygdala activityR00AA021802 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI LOGRIP, MARIAN LEE · 2015 to 2017
$747k
Sex differences in stress-alcohol interactions modulating amygdala activityK99AA021802 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI LOGRIP, MARIAN LEE · 2013 to 2014
$279k
NIAAA NIH HHS K99 AA021802NIAAA NIH HHS P50 AA006420NIAAA NIH HHS P60 AA006420NIAAA NIH HHS R00 AA021802NIAAA NIH HHS R01 AA015566NIAAA NIH HHS R01 AA017447NIAAA NIH HHS R01 AA021491NIAAA NIH HHS R37 AA017447NIAAA NIH HHS U01 AA013498
6 · The paper itself

Abstract

The central amygdala (CeA) GABAergic system is hypothesized to drive the development of alcohol dependence, due to its pivotal roles in the reinforcing actions of alcohol and the expression of negative emotion, anxiety and stress. Recent work has also identified an important role for the CeA corticotropin-releasing factor (CRF) system in the interaction between anxiety/stress and alcohol dependence. We have previously shown that acute alcohol and CRF each increase action potential-independent GABA release in the CeA via their actions at presynaptic CRF type 1 receptors (CRF

Indexed as

Alcohol-Related DisordersAmygdalaAnimalsCalcium Channels, P-TypeCalcium Channels, Q-TypeCentral Nervous System DepressantsCorticotropin-Releasing HormoneCRF Receptor, Type 1Disease Models, AnimalEthanolGABAergic Neuronsgamma-Aminobutyric AcidMaleRats, Sprague-DawleyReceptors, Corticotropin-Releasing HormoneSynapsesCalcium Channels, P-TypeCalcium Channels, Q-TypeCentral Nervous System DepressantsCorticotropin-Releasing HormoneCRF Receptor, Type 1Ethanolgamma-Aminobutyric AcidReceptors, Corticotropin-Releasing HormoneAlcohol dependenceAlcohol/ethanolCentral amygdalaCorticotropin-releasing factor (CRF)Corticotropin-releasing factor type 1 receptor (CRF(1))GABAP/Q-type voltage-gated calcium channel

Identifiers

PMID28734867
PMCPMC5837809
OpenAlexW2738615814

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.