Evidence map›Paper›PMID 28734816›Full record

ArticleAmerican journal of ophthalmology2017

Glaucoma Screening in Nepal: Cup-to-Disc Estimate With Standard Mydriatic Fundus Camera Compared to Portable Nonmydriatic Camera.

Sarah E Miller, Suman Thapa, Alan L Robin, Leslie M Niziol, Pradeep Y Ramulu, Maria A Woodward, Indira Paudyal, Ian Pitha, Tyson N Kim, Paula Anne Newman-Casey

Open access · greenAbstract readComparative StudyValidation Study
In one paragraph

Article in American journal of ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 42 citations in OpenAlex.

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  12. Deep learning-based automated detection of glaucomatous optic neuropathy on color fundus photographs.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020
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  17. Early diagnostics and interventional glaucoma.Therapeutic advances in ophthalmology
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Sarah E MillerSchool of Public Health, University of Michigan, Ann Arbor, Michigan.
Suman ThapaTilganga Institute of Ophthalmology, Kathmandu, Nepal.
Alan L RobinDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan; Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland; Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, Maryland.
Leslie M NiziolDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan.
Pradeep Y RamuluBloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland; Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, Maryland.
Maria A WoodwardDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan.
Indira PaudyalTilganga Institute of Ophthalmology, Kathmandu, Nepal.
Ian PithaWilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, Maryland.
Tyson N KimDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan.
Paula Anne Newman-CaseyDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan. Electronic address: panewman@med.umich.edu.
University of Michigan–Ann Arbor · USTilganga Institute of Ophthalmology · NPJohns Hopkins Medicine · USJohns Hopkins University · US

Funding

Telemedicine For Anterior Eye DiseasesK23EY023596 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WOODWARD, MARIA ANNEKE · 2013 to 2017
$1.1M
Improving glaucoma self-management with technology-supported counselorsK23EY025320 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NEWMAN-CASEY, PAULA ANNE · 2016 to 2019
$920k
NEI NIH HHS K23 EY023596NEI NIH HHS K23 EY025320
6 · The paper itself

Abstract

purposeTo compare cup-to-disc ratio (CDR) measurements from images taken with a portable, 45-degree nonmydriatic fundus camera to images from a traditional tabletop mydriatic fundus camera.

designProspective, cross-sectional, comparative instrument validation study.

methodsSetting: Clinic-based. STUDY POPULATION: A total of 422 eyes of 211 subjects were recruited from the Tilganga Institute of Ophthalmology (Kathmandu, Nepal). Two masked readers measured CDR and noted possible evidence of glaucoma (CDR ≥ 0.7 or the presence of a notch or disc hemorrhage) from fundus photographs taken with a nonmydriatic portable camera and a mydriatic standard camera. Each image was graded twice.

main outcome measuresEffect of camera modality on CDR measurement; inter- and intraobserver agreement for each camera for the diagnosis of glaucoma.

resultsA total of 196 eyes (46.5%) were diagnosed with glaucoma by chart review; 41.2%-59.0% of eyes were remotely diagnosed with glaucoma over grader, repeat measurement, and camera modality. There was no significant difference in CDR measurement between cameras after adjusting for grader and measurement order (estimate = 0.004, 95% confidence interval [CI], 0.003-0.011, P = .24). There was moderate interobserver reliability for the diagnosis of glaucoma (Pictor: κ = 0.54, CI, 0.46-0.61; Topcon: κ = 0.63, CI, 0.55-0.70) and moderate intraobserver agreement upon repeat grading (Pictor: κ = 0.63 and 0.64, for graders 1 and 2, respectively; Topcon: κ = 0.72 and 0.80, for graders 1 and 2, respectively).

conclusionsA portable, nonmydriatic, fundus camera can facilitate remote evaluation of disc images on par with standard mydriatic fundus photography.

Indexed as

Diagnostic Techniques, OphthalmologicalAdultCross-Sectional StudiesFemaleFluorescein AngiographyGlaucomaHumansMaleMass ScreeningMiddle AgedNepalObserver VariationOptic DiskOptic Nerve DiseasesPhotographyProspective Studies

Identifiers

PMID28734816
PMCPMC5610654
OpenAlexW2739090751

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.