Evidence map›Paper›PMID 28734628›Full record

ArticleThe Journal of thoracic and cardiovascular surgery2017

Adrenergic receptor genotypes influence postoperative outcomes in infants in the Single-Ventricle Reconstruction Trial.

Ronand Ramroop, George Manase, Danny Lu, Dorin Manase, Shan Chen, Richard Kim, Teresa Lee, William T Mahle, Kimberly McHugh, Mike Mitchell and 9 more

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of thoracic and cardiovascular surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00115934 (Trial of Right Ventricular Versus Modified Blalock-Taussig Shunt in Infants With Single Ventricle Defect Undergoing Staged Reconstruction), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00115934 nacompletednot on this map

Trial of Right Ventricular Versus Modified Blalock-Taussig Shunt in Infants With Single Ventricle Defect Undergoing Staged Reconstruction (A Trial Conducted by the Pediatric Heart Network)

TypeinterventionalSponsorCarelon ResearchRan2005 to 2009Enrolled555ConditionsHeart Defects, CongenitalArmsBlalock-Taussig pulmonary artery shunt, Right ventricular to pulmonary artery shunt
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Current state of the art in hypoplastic left heart syndrome.Frontiers in cardiovascular medicine · 2022
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 14 institutions in 2 countries.

Ronand RamroopHospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
George ManaseHospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Danny LuHospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Dorin ManaseHospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Shan ChenNew England Research Institute, Watertown, Mass.
Richard KimChildren's Hospital of Los Angeles, Los Angeles, Calif.
Teresa LeeColumbia University Medical Center, New York, NY.
William T MahleEmory University, Atlanta, Ga.
Kimberly McHughMedical University of South Carolina, Charleston, SC.
Mike MitchellChildren's Hospital of Wisconsin, Milwaukee, Wis.
Martin Tristani-FirouziUniversity of Utah School of Medicine, Salt Lake City, Utah.
Stephanie B WechslerDuke University Medical Center, Durham, NC.
Nicole S WilderUniversity of Michigan Health, Ann Arbor, Mich.
Victor ZakNew England Research Institute, Watertown, Mass.
Myriam Lafreniere-RoulaCardiovascular Data Management Centre, Hospital for Sick Children, Toronto, Ontario, Canada.
Jane W NewburgerBoston Children's Hospital, Boston, Mass.
J William GaynorChildren's Hospital of Philadelphia, Philadelphia, Pa.
Mark W RussellUniversity of Michigan Health, Ann Arbor, Mich.
Seema MitalHospital for Sick Children, University of Toronto, Toronto, Ontario, Canada. Electronic address: seema.mital@sickkids.ca.
SickKids Foundation · CANew England Research (United States) · USUniversity of Michigan–Ann Arbor · USUniversity of Toronto · CABoston Children's Museum · USChildren's Hospital of Los Angeles · USChildren's Hospital of Philadelphia · USChildren's Hospital of Wisconsin · USColumbia University Irving Medical Center · USDuke Medical Center · USEmory University · USHospital for Sick Children · CAMedical University of South Carolina · USUniversity of Utah · US

Funding

Pediatric Heart network DCCU10HL068270 · NHLBI · NEW ENGLAND RESEARCH INSTITUTES, INC. · PI MILLER, JULIE ELAINE, TRACHTENBERG, FELICIA LYNN · 2011 to 2016
$44.9M
Ventricular Volumes and Varability (VVV)U01HL068270 · NHLBI · NEW ENGLAND RESEARCH INSTITUTES, INC. · PI SLEEPER, LYNN A · 2001 to 2010
$40.3M
MIS-C Program: Data Coordinating Center for the Pediatric Heart Network MIS-C ProgramU24HL135691 · NHLBI · NEW ENGLAND RESEARCH INSTITUTES, INC. · PI MILLER, JULIE ELAINE, TRACHTENBERG, FELICIA LYNN · 2017 to 2024
$37.9M
Pediatric Heart Network: Follow-up of the Single Ventricle Reconstruction TrialU01HL068290 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LAI, WYMAN W · 2001 to 2010
$4.1M
Pediatric Heart Disease Network: CHOP MembershipU01HL068279 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI VETTER, VICTORIA L · 2001 to 2010
$3.7M
Randomized Therapeutic Trials in Pediatric Heart DiseaseU01HL068285 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI NEWBURGER, JANE W. · 2001 to 2010
$3.4M
Randomized Clinical Trials for Pediatric Heart DiseaseU01HL068281 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SAUL, J PHILIP · 2001 to 2010
$3.2M
Clinical and genomic responses to remote ischemic preconditioningU01HL068288 · NHLBI · HOSPITAL FOR SICK CHLDRN (TORONTO) · PI MCCRINDLE, BRIAN W · 2001 to 2010
$3.0M
Pediatric Heart Network Clinical Research Centers - Boston Children's HospitalUG1HL135685 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI NEWBURGER, JANE W., TRIEDMAN, JOHN K · 2017 to 2023
$2.7M
Intermountain Pediatric Heart Disease Research CenterU01HL068292 · NHLBI · UNIVERSITY OF UTAH · PI MINICH, L. LUANN · 2001 to 2010
$2.7M
The Duke-UNC-CH Pediatric Cardiology Clinical CenterU01HL068269 · NHLBI · DUKE UNIVERSITY · PI LI, JENNIFER S · 2001 to 2010
$2.6M
Pediatric Heart Network - Utah CenterUG1HL135646 · NHLBI · UNIVERSITY OF UTAH · PI MINICH, L. LUANN, WILLIAMS, RICHARD VINCENT · 2017 to 2023
$2.3M
NHLBI NIH HHS U01 HL068269NHLBI NIH HHS U01 HL068270NHLBI NIH HHS U01 HL068279NHLBI NIH HHS U01 HL068281NHLBI NIH HHS U01 HL068285NHLBI NIH HHS U01 HL068288NHLBI NIH HHS U01 HL068290NHLBI NIH HHS U01 HL068292NHLBI NIH HHS U01 HL085057NHLBI NIH HHS U10 HL068270NHLBI NIH HHS U10 HL109777NHLBI NIH HHS U10 HL109778NHLBI NIH HHS U24 HL135691NHLBI NIH HHS UG1 HL135646NHLBI NIH HHS UG1 HL135680NHLBI NIH HHS UG1 HL135685
6 · The paper itself

Abstract

objectivesAdrenergic receptor (ADR) genotypes have been associated with adverse outcomes in heart failure. Our objective was to evaluate the association of ADR genotypes with post-Norwood outcomes in infants with hypoplastic left heart syndrome (HLHS).

methodsInfants with HLHS participating in the Pediatric Heart Network Single-Ventricle Reconstruction Trial underwent genotyping for 4 single-nucleotide polymorphisms in 3 ADR genes: ADRB1_231A/G, ADRB1_1165G/C, ADRB2_5318C/G, and ADRA2A_2790C/T. The association of genotype with freedom from serious adverse events (SAEs) (death, transplant, extracorporeal membrane oxygenation, cardiopulmonary resuscitation, acute shunt failure, unplanned reoperations, or necrotizing enterocolitis) during 14 months' follow-up was assessed with Cox regression and the association with post-Norwood complications was assessed with Poisson regression. Models were adjusted for clinical and surgical factors.

resultsThe study included 351 eligible patients (62% male; 83% white). The mean age at Norwood procedure was 5.6 ± 3.6 days. A total of 152 patients had SAEs during 14-month follow-up including 84 deaths and 10 transplants. ADRA2A_2790CC genotype had lower SAE-free survival compared with CT/TT genotypes during follow-up (Log rank test, P = .02), and this association was independent of clinical and surgical risk factors (adjusted Cox regression, hazard ratio 1.54 [95% confidence interval 1.04, 2.30] P = .033). Post-Norwood complication rate did not differ by genotype.

conclusionsInfants with HLHS harboring ADR genotypes that are associated with greater catecholamine release or sensitivity had lower event-free survival after staged palliation. Excess catecholamine activation may adversely affect cardiovascular adaptation after the Norwood procedure. Future studies should explore whether targeting adrenergic activation in those harboring risk genotypes can improve outcomes. (ClinicalTrials.gov number NCT00115934).

Indexed as

Hypoplastic Left Heart SyndromePostoperative ComplicationsCorrelation of DataFemaleFollow-Up StudiesHumansInfant, NewbornMaleNorwood ProceduresPolymorphism, Single NucleotideProportional Hazards ModelsReceptors, Adrenergic, alpha-2Receptors, Adrenergic, beta-1Receptors, Adrenergic, beta-2ADRA2A protein, humanADRB1 protein, humanADRB2 protein, humanReceptors, Adrenergic, alpha-2Receptors, Adrenergic, beta-1Receptors, Adrenergic, beta-2adrenergic receptorscongenital heart surgerygeneticshypoplastic left heart syndrome

Identifiers

PMID28734628
PMCPMC5647218
OpenAlexW2705202854

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.