Evidence map›Paper›PMID 28734180›Full record

ArticleBiomaterials2017

Bottom-up assembly of salivary gland microtissues for assessing myoepithelial cell function.

Tugba Ozdemir, Padma Pradeepa Srinivasan, Daniel R Zakheim, Daniel A Harrington, Robert L Witt, Mary C Farach-Carson, Xinqiao Jia, Swati Pradhan-Bhatt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Crack Cocaine Smoke Induces Tissue Degeneration in Rat Submandibular Glands by Toll-like Signaling Pathway.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Hydrogels for Salivary Gland Tissue Engineering.Gels (Basel, Switzerland) · 2022
    Review
  11. Article
  12. Review
  13. Bioengineering in salivary gland regeneration.Journal of biomedical science · 2022
    Review
  14. Article
  15. Review
  16. Article
  17. EnablingJournal of the American Chemical Society · 2021
    Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Tugba OzdemirDepartment of Materials Sciences and Engineering, University of Delaware, Newark, DE, USA.
Padma Pradeepa SrinivasanDepartment of Biological Sciences, University of Delaware, Newark, DE, USA; Center for Translational Cancer Research, Helen F. Graham Cancer Center & Research Institute, Newark, DE, USA.
Daniel R ZakheimDepartment of Biological Sciences, University of Delaware, Newark, DE, USA.
Daniel A HarringtonBioSciences, Rice University, Houston, TX, USA; Diagnostic and Biomedical Sciences, University of Texas Health Science Center at Houston School of Dentistry, Houston, TX, USA.
Robert L WittDepartment of Biological Sciences, University of Delaware, Newark, DE, USA; Otolaryngology - Head & Neck Surgery, Thomas Jefferson University, Philadelphia, PA, USA.
Mary C Farach-CarsonDepartment of Biological Sciences, University of Delaware, Newark, DE, USA; BioSciences, Rice University, Houston, TX, USA; Diagnostic and Biomedical Sciences, University of Texas Health Science Center at Houston School of Dentistry, Houston, TX, USA.
Xinqiao JiaDepartment of Materials Sciences and Engineering, University of Delaware, Newark, DE, USA; Department of Biological Sciences, University of Delaware, Newark, DE, USA; Department of Biomedical Engineering, University of Delaware, Newark, DE, USA. Electronic address: xjia@udel.edu.
Swati Pradhan-BhattDepartment of Biological Sciences, University of Delaware, Newark, DE, USA; Center for Translational Cancer Research, Helen F. Graham Cancer Center & Research Institute, Newark, DE, USA; Department of Biomedical Engineering, University of Delaware, Newark, DE, USA. Electronic address: swati@udel.edu.
University of Delaware · USRice University · USCenter for Cancer Research · US

Funding

Functional Assembly of Salivary Cells to Relieve XerostomiaR01DE022969 · NIDCR · RICE UNIVERSITY · PI FARACH-CARSON, MARY C, JIA, XINQIAO · 2012 to 2015
$2.5M
NIDCR NIH HHS R01 DE022969
6 · The paper itself

Abstract

Myoepithelial cells are flat, stellate cells present in exocrine tissues including the salivary glands. While myoepithelial cells have been studied extensively in mammary and lacrimal gland tissues, less is known of the function of myoepithelial cells derived from human salivary glands. Several groups have isolated tumorigenic myoepithelial cells from cancer specimens, however, only one report has demonstrated isolation of normal human salivary myoepithelial cells needed for use in salivary gland tissue engineering applications. Establishing a functional organoid model consisting of myoepithelial and secretory acinar cells is therefore necessary for understanding the coordinated action of these two cell types in unidirectional fluid secretion. Here, we developed a bottom-up approach for generating salivary gland microtissues using primary human salivary myoepithelial cells (hSMECs) and stem/progenitor cells (hS/PCs) isolated from normal salivary gland tissues. Phenotypic characterization of isolated hSMECs confirmed that a myoepithelial cell phenotype consistent with that from other exocrine tissues was maintained over multiple passages of culture. Additionally, hSMECs secreted basement membrane proteins, expressed adrenergic and cholinergic neurotransmitter receptors, and released intracellular calcium [Ca

Indexed as

CalciumCell SeparationCollagen Type IEpithelial CellsHumansHydrogel, Polyethylene Glycol DimethacrylateMuscarinic AgonistsNeurotransmitter AgentsPhenotypeReceptors, MuscarinicSalivary GlandsSpheroids, CellularTissue EngineeringCalciumCollagen Type IHydrogel, Polyethylene Glycol DimethacrylateMuscarinic AgonistsNeurotransmitter AgentsReceptors, MuscarinicMicrotissuesMyoepithelial cellsSalivary glandsSelf-assemblySpheroidsStem/progenitor cells

Identifiers

PMID28734180
PMCPMC5561745
OpenAlexW2735538582

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.