ArticleHuman brain mapping2017
Localized reductions in resting-state functional connectivity in children with prenatal alcohol exposure.
Article in Human brain mapping, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Developmental Neurotoxicity of Alcohol from Neuronal Basis to Behavioural Outcomes: A Comprehensive Review.Neurology international · 2026Review
- Persistent Alterations of Brain and Behavior in Children With Low Prenatal Alcohol Exposure.Biological psychiatry global open science · 2026Article
- Impact of Prenatal Alcohol Exposure on Cerebral Cortex Development.Advances in experimental medicine and biology · 2026Review
- Lower resting state functional connectivity partially mediates adverse effects of prenatal alcohol exposure on arithmetic performance in children.Alcohol, clinical & experimental research · 2024Article
- The relationship between negative life events and cortical structural connectivity in adolescents.IBRO neuroscience reports · 2024Article
- Functional connectivity of cognition-related brain networks in adults with fetal alcohol syndrome.BMC medicine · 2023Article
- Altered functional connectivity and oscillatory dynamics in polysubstance and cannabis only users during visuospatial processing.Psychopharmacology · 2023Article
- Disrupted dynamic functional network connectivity in fetal alcohol spectrum disorders.Alcohol, clinical & experimental research · 2023Article
- Vascular Contributions to the Neurobiological Effects of Prenatal Alcohol Exposure.Advances in drug and alcohol research · 2023Article
- Sex-specific effects of prenatal undernutrition on resting-state functional connectivity in the human brain at age 68.Neurobiology of aging · 2022Article
- Evaluation of Brain Alterations and Behavior in Children With Low Levels of Prenatal Alcohol Exposure.JAMA network open · 2022Article
- Pilot Study on Analysis of Electroencephalography Signals from Children with FASD with the Implementation of Naive Bayesian Classifiers.Sensors (Basel, Switzerland) · 2021Article
- Ethanol effects on cerebellar myelination in a postnatal mouse model of fetal alcohol spectrum disorders.Alcohol (Fayetteville, N.Y.) · 2021Article
- Disruptions in global network segregation and integration in adolescents and young adults with fetal alcohol spectrum disorder.Alcoholism, clinical and experimental research · 2021Article
- Functional connectivity of the attention networks is altered and relates to neuropsychological outcomes in children with prenatal alcohol exposure.Developmental cognitive neuroscience · 2021Article
- Association of Prenatal Alcohol Exposure With Psychological, Behavioral, and Neurodevelopmental Outcomes in Children From the Adolescent Brain Cognitive Development Study.The American journal of psychiatry · 2020Article
- Omission of temporal nuisance regressors from dual regression can improve accuracy of fMRI functional connectivity maps.Human brain mapping · 2019Article
- Clinical presentation, diagnosis, and management of fetal alcohol spectrum disorder.The Lancet. Neurology · 2019Review
- Quantitative assessment of cerebral connectivity deficiency and cognitive impairment in children with prenatal alcohol exposure.Chaos (Woodbury, N.Y.) · 2019Article
- The brain's functional connectome in young children with prenatal alcohol exposure.NeuroImage. Clinical · 2019Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Fetal alcohol spectrum disorders (FASD) are characterized by impairment in cognitive function that may or may not be accompanied by craniofacial anomalies, microcephaly, and/or growth retardation. Resting-state functional MRI (rs-fMRI), which examines the low-frequency component of the blood oxygen level dependent (BOLD) signal in the absence of an explicit task, provides an efficient and powerful mechanism for studying functional brain networks even in low-functioning and young subjects. Studies using independent component analysis (ICA) have identified a set of resting-state networks (RSNs) that have been linked to distinct domains of cognitive and perceptual function, which are believed to reflect the intrinsic functional architecture of the brain. This study is the first to examine resting-state functional connectivity within these RSNs in FASD. Rs-fMRI scans were performed on 38 children with FASD (19 with either full fetal alcohol syndrome (FAS) or partial FAS (PFAS), 19 nonsyndromal heavily exposed (HE)), and 19 controls, mean age 11.3 ± 0.9 years, from the Cape Town Longitudinal Cohort. Nine resting-state networks were generated by ICA. Voxelwise group comparison between a combined FAS/PFAS group and controls revealed localized dose-dependent functional connectivity reductions in five regions in separate networks: anterior default mode, salience, ventral and dorsal attention, and R executive control. The former three also showed lower connectivity in the HE group. Gray matter connectivity deficits in four of the five networks appear to be related to deficits in white matter tracts that provide intra-RSN connections. Hum Brain Mapp 38:5217-5233, 2017. © 2017 Wiley Periodicals, Inc.
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