ArticleThe journal of headache and pain2017
Assessment of gray and white matter structural alterations in migraineurs without aura.
Article in The journal of headache and pain, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.
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Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Microstructural white matter alterations associated with migraine headaches: a systematic review of diffusion tensor imaging studies.Brain imaging and behavior · 2022Pooled it
- Is Migraine Associated to Brain Anatomical Alterations? New Data and Coordinate-Based Meta-analysis.Brain topography · 2021Pooled it
- Cortical Thickness in Migraine: A Coordinate-Based Meta-Analysis.Frontiers in neuroscience · 2020Pooled it
- Acupuncture at Zuqiaoyin (GB44) Modulates Regional Brain Activity in Migraine Without Aura: A Resting-State Functional Magnetic Resonance Imaging Study.Pain research & management · 2026Trial
- Altered cortical morphology and structural covariance network in chronic neck and shoulder pain.Neuroradiology · 2026Article
- Brain imaging-wide exploration of site-specific pain: genetic correlation and Mendelian randomization study.Psychological medicine · 2026Article
- White matter and cortical gray matter microstructural alterations in migraine: a NODDI and DTI analysis.The journal of headache and pain · 2025Article
- Article
- Cerebral morphometric alterations predict the outcome of migraine diagnosis and subtyping: a radiomics analysis.BMC medical imaging · 2025Article
- Review
- Analysis of the relationships between the degree of migraine with right-to-left shunts and changes in white matter lesions and brain structural volume.Scientific reports · 2025Article
- Association between white matter microstructural and functional abnormalities and clinical characteristics in migraine without aura: a mediation analysis.Frontiers in neurology · 2025Article
- Aberrant cerebral blood flow and functional connectivity in patients with vestibular migraine: a resting-state ASL and fMRI study.The journal of headache and pain · 2024Article
- Revealing the mechanism of central pain hypersensitivity in primary dysmenorrhea: evidence from neuroimaging.Quantitative imaging in medicine and surgery · 2024Article
- Cortical thickness and white matter microstructure predict freezing of gait development in Parkinson's disease.NPJ Parkinson's disease · 2024Article
- Two distinct neuroanatomical subtypes of migraine without aura revealed by heterogeneity through discriminative analysis.Brain imaging and behavior · 2023Article
- Structural integrity of corpus callosum in patients with migraine: a diffusion tensor imaging study.Acta neurologica Belgica · 2023Article
- Decreased ALFF and Functional Connectivity of the Thalamus in Vestibular Migraine Patients.Brain sciences · 2023Article
- The Patent Foramen Ovale and Migraine: Associated Mechanisms and Perspectives from MRI Evidence.Brain sciences · 2022Review
- The brain structure and function abnormalities of migraineurs: A systematic review and neuroimaging meta-analysis.Frontiers in neurology · 2022Review
Corrections and comments
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Authors and funding
17 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMigraine constitute a disorder characterized by recurrent headaches, and have a high prevalence, a high socio-economic burden and severe effects on quality of life. Our previous fMRI study demonstrated that some brain regions are functional alterations in migraineurs. As the function of the human brain is related to its structure, we further investigated white and gray matter structural alterations in migraineurs.
methodsIn current study, we used surface-based morphometry, voxel-based morphometry and diffusion tensor imaging analyses to detect structural alterations of the white matter and gray matter in 32 migraineurs without aura compared with 32 age- and gender-matched healthy controls.
resultsWe found that migraineurs without aura exhibited significantly increased gray matter volume in the bilateral cerebellar culmen, increased cortical thickness in the lateral occipital-temporal cortex, decreased cortical thickness in the right insula, increased gyrification index in left postcentral gyrus, superior parietal lobule and right lateral occipital cortex, and decreased gyrification index in the left rostral middle frontal gyrus compared with controls. No significant change in white matter microstructure was found in DTI analyses.
conclusionThe significantly altered gray matter brain regions were known to be associated with sensory discrimination of pain, multi-sensory integration and nociceptive information processing and were consistent with our previous fMRI study, and may be involved in the pathological mechanism of migraine without aura.
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