Evidence map›Paper›PMID 28733811›Full record

ArticlePsychopharmacology2017

Pharmacological evidence that 5-HT

Wendy K Adams, Chris Barkus, Jacqueline-Marie N Ferland, Trevor Sharp, Catharine A Winstanley

Abstract read
PubMed Publisher
In one paragraph

Article in Psychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. DThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  6. Article
  7. 5-HTPsychopharmacology · 2022
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Understanding Addiction Using Animal Models.Frontiers in behavioral neuroscience · 2019
    Article
  15. Review
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Wendy K AdamsDepartment of Psychology, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada.
Chris BarkusDepartment of Psychology, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada.
Jacqueline-Marie N FerlandDepartment of Psychology, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada.
Trevor SharpDepartment of Pharmacology, University of Oxford, Oxford, UK.
Catharine A WinstanleyDepartment of Psychology, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada. cwinstanley@psych.ubc.ca.
University of British Columbia · CAUniversity of Oxford · GB

Funding

Institute of Neurosciences, Mental Health and Addiction New Investigator AwardMedical Research Council DPFS grant, MR/L013150/1Medical Research Council MR/L013150/1
6 · The paper itself

Abstract

rationaleAdding reward-concurrent cues to a rat gambling task (rGT) increases risky choice. This cued version of the task may reflect an "addiction-like" cognitive process, more similar to human gambling than the uncued task. Serotonergic drugs that target 5-HT

objectivesThe aim of this study was to determine the effects of SB 242,084 and M100907, selective antagonists at the 5-HT

resultsSB 242,084 significantly and dose-dependently increased choice of the most optimal option in the cued rGT only, despite concurrently increasing impulsive responses made prematurely on both the cued and uncued rGT. M100907 and Ro-60-0175 did not alter risky decision making, but nevertheless produced the expected decrease in premature responses on both task variants.

conclusionsThese findings demonstrate that the 5-HT

Indexed as

CuesReceptor, Serotonin, 5-HT2CRewardAcoustic StimulationAnimalsConditioning, OperantDecision MakingDose-Response Relationship, DrugEthylaminesGamblingIndolesMalePhotic StimulationRatsRats, Long-EvansSerotonin 5-HT2 Receptor AntagonistsEthylaminesIndolesReceptor, Serotonin, 5-HT2CRo 60-0175Serotonin 5-HT2 Receptor Antagonists5-HT2A5-HT2CImpulsivityRisky decision makingSB 242,084Serotonin

Identifiers

PMID28733811
OpenAlexW2736883730

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.