ArticlePharmaceutical research2017
BITC and S-Carvone Restrain High-Fat Diet-Induced Obesity and Ameliorate Hepatic Steatosis and Insulin Resistance.
Article in Pharmaceutical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 56 citations in OpenAlex.
- Molecular Targets and Biological Activities of Carvone: An Evidence-Graded Review.Molecules (Basel, Switzerland) · 2026Review
- Benzyl isothiocyanate improves the prognosis ofFrontiers in microbiology · 2023Article
- Essential Oil of Carvone ChemotypeCurrent issues in molecular biology · 2022Article
- Ameliorative Effect of D-Carvone against Hepatic Ischemia-Reperfusion-Induced Injury in Rats.Life (Basel, Switzerland) · 2022Article
- D-Carvone Attenuates CClBiology · 2022Article
- The pinene scaffold: its occurrence, chemistry, synthetic utility, and pharmacological importance.RSC advances · 2022Review
- Health Benefits and Pharmacological Properties of Carvone.Biomolecules · 2021Review
- Article
- Exploring the Critical Components and Therapeutic Mechanisms ofFrontiers in pharmacology · 2021Article
- Bioactivity-Guided Identification of Anti-Adipogenic Isothiocyanates in the Moringa (Molecules (Basel, Switzerland) · 2020Article
- A high-fat diet impacts memory and gene expression of the head in mated female Drosophila melanogaster.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo investigate the preventative activity of benzyl isothiocyante and S-carvone against high-fat diet-induced obesity and metabolic complications.
methodsTen-week-old C57BL/6 male mice were fed a high-fat diet and injected intraperitoneally twice per week with benzyl isothiocyante, S-carvone, or vehicle for 8 weeks. The body weight, food intake, and body composition were monitored, and glucose tolerance and insulin tolerance tests were performed at the end of the experiment. Serum and tissue samples were studied using serum biochemistry, histological, and gene expression analysis to define the effects of benzyl isothiocyante and S-carvone treatments on lipid and glucose metabolism and inflammatory responses.
resultsBenzyl isothiocyante and S-carvone blocked high-fat diet-induced weight gain, fat accumulation in the liver, and insulin resistance. The beneficial effects were found to be associated with an improvement of expression of macrophage marker genes in white adipose tissue, including F4/80, Cd11b, Cd11c, Cd206, and Tnf-α, and reduced expression of genes (Pparγ2, Scd1, Cd36) responsible for lipid synthesis and transport in the liver.
conclusionBenzyl isothiocyante and S-carvone block high-fat diet-induced obesity and metabolism disorders and can be considered for management of the obesity epidemic that affects approximately 36% of adults and 17% of children in the USA.
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