ArticleEuropean journal of nuclear medicine and molecular imaging2017
Cardiac sympathetic neuronal damage precedes myocardial fibrosis in patients with Anderson-Fabry disease.
Article in European journal of nuclear medicine and molecular imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Unveiling Functional Impairment in Fabry Disease: The Role of Peripheral vs. Cardiac Mechanisms.Biomedicines · 2025Article
- Contemporary Multimodality Imaging for Diagnosis and Management of Fabry Cardiomyopathy.Journal of clinical medicine · 2024Review
- Cardiac involvement in Anderson-Fabry disease. The role of advanced echocardiography.Frontiers in cardiovascular medicine · 2024Review
- Detection of sympathetic denervation defects in Fabry disease by hybrid [Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Impairment of sympathetic activity in Fabry disease cardiomyopathy: A further challenge for cardiac imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Role of Imaging in Cardiomyopathies.Cardiac failure review · 2023Review
- Multimodality imaging approach to Fabry cardiomyopathy: Any role for nuclear cardiology?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Review
- Multimodality Imaging in Cardiomyopathies with Hypertrophic Phenotypes.Journal of clinical medicine · 2022Review
- Multimodality Cardiac Imaging in Cardiomyopathies: From Diagnosis to Prognosis.Journal of clinical medicine · 2022Review
- New insights for early assessment of cardiac involvement in Anderson-Fabry disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Cardiac Imaging in Anderson-Fabry Disease: Past, Present and Future.Journal of clinical medicine · 2021Review
- Review
- Fabry Disease and the Heart: A Comprehensive Review.International journal of molecular sciences · 2021Review
- Focal reduction in left ventricularJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Myocardial ischaemia reperfusion injury and cardioprotection in the presence of sensory neuropathy: Therapeutic options.British journal of pharmacology · 2020Review
- Article
- Left Ventricular Mass in Hypertrophic Cardiomyopathy Assessed by 2D-Echocardiography: Validation with Magnetic Resonance Imaging.Journal of cardiovascular translational research · 2020Article
- Cardiac amyloidosis: A new challenge of multimodality imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Behind Traditional Semi-quantitative Scores of Myocardial Perfusion Imaging: An Eye on Niche Parameters.European cardiology · 2019Review
- SPECT vs. PET in cardiac innervation imaging: clash of the titans.Clinical and translational imaging · 2018Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCardiac sympathetic denervation may be detectable in patients with Anderson-Fabry disease (AFD), suggesting its usefulness for early detection of the disease. However, the relationship between sympathetic neuronal damage measured by
methodsCardiac sympathetic innervation was assessed by
resultsPatients were divided into three groups according to MIBG and CMR findings: (1) matched normal, without MIBG defects and without fibrosis on CMR (n = 10); (2) unmatched, with MIBG defect but without fibrosis (n = 5); and (3) matched abnormal, with MIBG defect and fibrosis (n = 10). The three groups did not differ with respect to age, gender, α-galactosidase, proteinuria, glomerular filtration rate, and troponin I, while New York Heart Association class (p = 0.008), LV hypertrophy (p = 0.05), and enzyme replacement therapy (p = 0.02) were different among groups. Although in patients with matched abnormal findings, there was a significant correlation between MIBG defect size and area of fibrosis at CMR (r
conclusionSympathetic neuronal damage is frequent in AFD patients, and it may precede myocardial damage, such as fibrosis. Thus,
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.