ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2017
Clinical performance of an updated trabecular bone score (TBS) algorithm in men and women: the Manitoba BMD cohort.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- The influence of physical activity intensity on bone mineral density and trabecular bone score in young adults with overweight and obesity.International journal of obesity (2005) · 2025Trial
- VITamin D and OmegA-3 TriaL (VITAL) bone health ancillary study: clinical factors associated with trabecular bone score in women and men.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Trial
- The Added Value of Trabecular Bone Score in Evaluating Fracture Risk Among Polish Women Aged 40-76 Years.Journal of clinical medicine · 2026Article
- Is trabecular bone score associated with appendicular lean mass?Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Article
- Bone microstructure and TBS in diabetes: what have we learned? A narrative review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Review
- Advancing trabecular bone score (TBS): clinical performance of TBS version 4.0 with direct correction for soft tissue thickness-the osteolaus study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Article
- Does Radiofrequency Echographic Multi-Spectrometry (REMS) perform similarly to Dual-energy X-ray Absorptiometry (DXA) in terms of Trabecular Bone Score (TBS) and FRAX?Archives of endocrinology and metabolism · 2025Article
- Assessment of trabecular bone score using updated TBSTT in anorexia nervosa-The AN-BO study.PloS one · 2024Article
- Waist circumference, among metabolic syndrome components, predicts degraded trabecular bone score: a retrospective study of a female population from the 2005-2008 NHANES cohorts.Frontiers in endocrinology · 2024Article
- Trabecular Bone Score in Individuals with Chronic Spinal Cord Injury: A Cross-Sectional Study.Topics in spinal cord injury rehabilitation · 2024Article
- Trabecular Bone Score Preceding and during a 2-Year Follow-Up after Sleeve Gastrectomy: Pitfalls and New Insights.Nutrients · 2023Article
- Fracture risk gradient assessed by categories of bone mineral density and trabecular bone score: the Manitoba BMD Registry.Archives of osteoporosis · 2023Article
- The effect of body size and composition on lumbar spine trabecular bone score in morphologically diverse subjects.PloS one · 2023Article
- Updated trabecular bone score accounting for the soft tissue thickness (TBSOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Article
- Older Women who are Overweight or Obese Have Vertebral Abnormalities, Partially Degraded TBS, and BMD that Worsen with Weight Loss.Calcified tissue international · 2022Article
- Low Turnover Renal Osteodystrophy With Abnormal Bone Quality and Vascular Calcification in Patients With Mild-to-Moderate CKD.Kidney international reports · 2022Article
- Body Composition as a Modulator of Bone Health Changes in Patients with Inflammatory Bowel Disease.Life (Basel, Switzerland) · 2022Article
- Bone Quality in CKD Patients: Current Concepts and Future Directions - Part I.Kidney diseases (Basel, Switzerland) · 2021Review
- Application of the Trabecular Bone Score in Clinical Practice.Journal of bone metabolism · 2021Article
- Trabecular bone deterioration in differentiated thyroid cancer: Impact of long-term TSH suppressive therapy.Cancer medicine · 2020Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This is the first study to directly compare the original and recently updated versions of the trabecular bone score (TBS) algorithm. We confirmed improved performance of the new algorithm, especially among men.
introductionLumbar spine trabecular bone score (TBS) predicts major osteoporotic fractures (MOFs) and hip fractures (HFs) independent of bone density. The original TBS algorithm (version 1; [TBS-v1]) was optimized for women of average body size. Limitations were identified when used in men or extremes of body mass index (BMI). The current study evaluates an updated TBS algorithm (version 2; [TBS-v2]) modified to address these issues.
methodsFrom a registry with all DXA results for Manitoba, Canada, we identified 47,736 women and 4348 men age ≥ 40 with baseline spine DXA (GE Prodigy, 1999-2011). Spine TBS was measured using both TBS-v1 and TBS-v2 algorithms. Risk stratification for incident fractures identified from population-based data was assessed from area under the receiver operating characteristic curve (AUROC).
resultsWith the TBS-v1 algorithm, average TBS for men was significantly lower than for women (p < 0.001) and showed significant inverse correlations with BMI (Pearson r-0.40 in men, -0.18 in women [both p < 0.001]). With the TBS-v2 algorithm, average values for men were slightly greater than for women (p < 0.001) and there were no significant correlations with BMI (Pearson r 0.01 in men, -0.01 in women [both p > 0.1]). During mean follow-up of 5 years in men, there were 214 incident MOFs and 47 HFs; during 6 years mean follow-up in women, there were 2895 incident MOFs and 694 HFs. Improvements in fracture prediction were seen with TBS-v2 in both men (change in AUROC for MOFs +0.021 [p = 0.17], HFs +0.046 [p = 0.04]) and women (change in AUROC for MOFs +0.012 [p < 0.001], HFs +0.020 [p < 0.001]).
conclusionThe updated TBS algorithm is less affected by BMI, gives higher mean results for men than women consistent with their lower fracture risk, and improves fracture prediction in both men and women.
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