ArticleScientific reports2017
Modulation of water diffusion by activation-induced neural cell swelling in Aplysia Californica.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 40 citations in OpenAlex.
- Article
- 40 Years of diffusion MRI in the brain: From history to emerging frontiers.Imaging neuroscience (Cambridge, Mass.) · 2026Review
- Synaptic micromechanics and brain softening as a mechanobiological hypothesis for Alzheimer's disease.Frontiers in neuroscience · 2026Article
- Distinct cellular processes drive motor skill learning in the human brain.bioRxiv : the preprint server for biology · 2025Article
- Uncovering the Role of the Human Hippocampus in Procedural Motor Learning: Insights from Implicit Sensorimotor Adaptation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Somatosensory-evoked response induces extensive diffusivity and kurtosis changes associated with neural activity in rodents.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- From Brownian motion to virtual biopsy: a historical perspective from 40 years of diffusion MRI.Japanese journal of radiology · 2024Review
- Relationship between regional volume changes and water diffusion in fixed marmoset brains: an in vivo and ex vivo comparison.Scientific reports · 2024Article
- Disentangling the impact of cerebrospinal fluid formation and neuronal activity on solute clearance from the brain.Fluids and barriers of the CNS · 2023Article
- Potential of Multiscale Astrocyte Imaging for Revealing Mechanisms Underlying Neurodevelopmental Disorders.International journal of molecular sciences · 2021Review
- Emerging imaging methods to study whole-brain function in rodent models.Translational psychiatry · 2021Review
- Visualization of live, mammalian neurons during Kainate-infusion using magnetic resonance microscopy.NeuroImage · 2020Article
- Differential effects of aquaporin-4 channel inhibition on BOLD fMRI and diffusion fMRI responses in mouse visual cortex.PloS one · 2020Article
- A CMOS NMR needle for probing brain physiology with high spatial and temporal resolution.Nature methods · 2020Article
- Apparent diffusion coefficient changes in human brain during sleep - Does it inform on the existence of a glymphatic system?NeuroImage · 2019Article
- Functional MRI Readouts From BOLD and Diffusion Measurements Differentially Respond to Optogenetic Activation and Tissue Heating.Frontiers in neuroscience · 2019Article
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5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Diffusion functional magnetic resonance imaging (DfMRI) has been proposed as a method for functional neuroimaging studies, as an alternative to blood oxygenation level dependent (BOLD)-fMRI. DfMRI is thought to more directly reflect neural activation, but its exact mechanism remains unclear. It has been hypothesized that the water apparent diffusion coefficient (ADC) decrease observed upon neural activation results from swelling of neurons or neuron parts. To elucidate the origin of the DfMRI response at cellular level we performed diffusion MR microscopy at 17.2 T in Aplysia californica buccal ganglia and compared the water ADCs at cellular and ganglia levels before and after neuronal activation induced by perfusion with a solution containing dopamine. Neural cell swelling, evidenced from optical microscopy imaging, resulted in an intracellular ADC increase and an ADC decrease at ganglia level. Furthermore, the intracellular ADC increase was found to have a significant positive correlation with the increase in cell size. Our results strongly support the hypothesis that the ADC decrease observed with DfMRI upon neuronal activation at tissue level reflects activation-induced neural cell swelling.
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