Evidence map›Paper›PMID 28733665›Full record

ArticleScientific reports2017

Human intrahepatic CD69 + CD8+ T cells have a tissue resident memory T cell phenotype with reduced cytolytic capacity.

Femke Stelma, Annikki de Niet, Marjan J Sinnige, Karel A van Dort, Klaas P J M van Gisbergen, Joanne Verheij, Ester M M van Leeuwen, Neeltje A Kootstra, Hendrik W Reesink

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 104 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Tissue-resident memory CD8Nature reviews. Gastroenterology & hepatology · 2025
    Review
  6. Single-cell transcriptional landscape of liver transplant rejection reveals tissue persistence of clonally expanded, treatment-resistant T cells.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025
    Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Expansion of CD103Frontiers in immunology · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. IRG1/Itaconate inhibits proliferation and promotes apoptosis of CD69Apoptosis : an international journal on programmed cell death · 2024
    Article
  19. Article
  20. Article

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Femke StelmaDepartment of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands.
Annikki de NietDepartment of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands.
Marjan J SinnigeDepartment of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands.
Karel A van DortDepartment of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands.
Klaas P J M van GisbergenDepartment of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, Amsterdam, Netherlands.
Joanne VerheijDepartment of Pathology, Academic Medical Center, Amsterdam, The Netherlands.
Ester M M van LeeuwenDepartment of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands.
Neeltje A KootstraDepartment of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands.
Hendrik W ReesinkDepartment of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands. h.w.reesink@amc.nl.
Academic Medical Center · NLSanquin · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tissue resident memory T cells (T

Indexed as

AdultAgedAged, 80 and overAntigens, CDAntigens, Differentiation, T-LymphocyteCD69 AntigensCD8-Positive T-LymphocytesFemaleHepatitis B, ChronicHepatitis C, ChronicHumansImmunologic MemoryIntegrin alpha ChainsKruppel-Like Transcription FactorsLectins, C-TypeLeukocytes, Mononuclearalpha E integrinsAntigens, CDAntigens, Differentiation, T-LymphocyteCD69 AntigensIntegrin alpha ChainsKLF2 protein, humanKruppel-Like Transcription FactorsLectins, C-TypeReceptors, LysosphingolipidS1PR1 protein, humanSphingosine-1-Phosphate Receptors

Identifiers

PMID28733665
PMCPMC5522381
OpenAlexW2735798685

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.