ArticleScientific reports2017
GeneXpert MTB/RIF assay in the diagnosis of urinary tuberculosis from urine specimens.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 51 citations in OpenAlex.
- An Evidence Atlas of Diagnostic Tests for Genitourinary Tuberculosis: A Laboratory-Centered Framework.International journal of general medicine · 2026Review
- Article
- The value of Xpert MTB/RIF assay of urine samples in the early diagnosis of smear-negative urinary tuberculosis.European journal of medical research · 2022Article
- Epidemiological characteristics of extrapulmonary tuberculosis patients with or without pulmonary tuberculosis.Epidemiology and infection · 2022Article
- Small contracted bladders posing bigger problems: Etiology, presentation, and management and a short review of literature.Journal of family medicine and primary care · 2022Article
- Disseminated Mycobacterium Tuberculosis and IgA Nephropathy.Case reports in nephrology · 2022Article
- The Value of GeneXpert MTB/RIF for Detection in Tuberculosis: A Bibliometrics-Based Analysis and Review.Journal of analytical methods in chemistry · 2022Review
- Microbiological diagnosis in urogenital tuberculosis: the Holy Grail still Eludes.World journal of urology · 2021Article
- Highly specific and sensitive detection of the Mycobacterium tuberculosis complex using multiplex loop-mediated isothermal amplification combined with a nanoparticle-based lateral flow biosensor.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- Urinary tuberculosis: still a challenge.World journal of urology · 2020Review
- Low diagnostic accuracy of Xpert MTB/RIF assay for extrapulmonary tuberculosis: A multicenter surveillance.Scientific reports · 2019Article
- Urogenital tuberculosis - epidemiology, pathogenesis and clinical features.Nature reviews. Urology · 2019Review
- Multicentre evaluation of Xpert MTB/RIF assay in detecting urinary tract tuberculosis with urine samples.Scientific reports · 2019Article
- Curious case of fever of unknown origin.BMJ case reports · 2018Article
- Detection of Mycobacterium tuberculosis in urine by Xpert MTB/RIF Ultra: A useful adjunctive diagnostic tool in HIV-associated tuberculosis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2018Article
- GeneXpert MTB/RIF Outperforms Mycobacterial Culture in DetectingBioMed research international · 2018Observational
- Urogenital Tuberculosis: A Narrative Review and recommendations for diagnosis and treatment.International braz j urol : official journal of the Brazilian Society of UrologyReview
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conventional bacteriological methods are not generally helpful in diagnosing urinary tuberculosis (UTB). GeneXpert is endorsed for the detection of pulmonary tuberculosis, whereas the data on its utility for urine specimens is limited. In this study, we aimed to evaluate its performance on urine specimens in a country with high TB incidence. A total of 163 suspected UTB patients were consecutively enrolled in the analysis, including 37 (22.7%) culture-positive and 44 (27.0%) clinically diagnosed UTB cases. Compared with conventional culture, the sensitivity of GeneXpert (94.6%) was significantly higher than that of smear microscopy (40.5%, P < 0.001). When setting clinical diagnosis as gold standard, 51 out of 81 clinically diagnosed UTB cases were detected by GeneXpert, demonstrating a sensitivity of 63.0%, which was significantly higher than that of smear microscopy (18.5%, P < 0.001) and culture (45.7%, P = 0.027), respectively. In addition, the proportion of UTB cases in the migrant population was significantly higher than that in the resident population (P = 0.019). To conclude, our data demonstrate that GeneXpert outperforms AFB smear and culture for the detection of MTB in urine samples, which provides an alternative for the diagnosis of UTB. The migrant population and previously diagnosed TB cases are high risk factors for developing UTB cases.
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