Evidence map›Paper›PMID 28733457›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2017

Role of bone morphogenetic proteins in sprouting angiogenesis: differential BMP receptor-dependent signaling pathways balance stalk

Andreas Benn, Christian Hiepen, Marc Osterland, Christof Schütte, An Zwijsen, Petra Knaus

Open access · hybridAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 82 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Endothelial-specific loss of IKKβ disrupts pulmonary endothelial angiogenesis and impairs postnatal lung growth.American journal of physiology. Lung cellular and molecular physiology · 2023
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Andreas BennInstitute for Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.
Christian HiepenInstitute for Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.
Marc OsterlandZuse Institute Berlin, Berlin, Germany.
Christof SchütteZuse Institute Berlin, Berlin, Germany.
An ZwijsenVlaams Instituut voor Biotechnologie (VIB) Center for Brain and Disease Research, KU Leuven, Leuven, Belgium.
Petra KnausInstitute for Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany; knaus@chemie.fu-berlin.de.
Freie Universität Berlin · DEVIB-KU Leuven Center for Brain & Disease Research · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Before the onset of sprouting angiogenesis, the endothelium is prepatterned for the positioning of tip and stalk cells. Both cell identities are not static, as endothelial cells (ECs) constantly compete for the tip cell position in a dynamic fashion. Here, we show that both bone morphogenetic protein 2 (BMP2) and BMP6 are proangiogenic

Indexed as

Activin Receptors, Type IAdaptor Proteins, Signal TransducingBone Morphogenetic Protein 2Bone Morphogenetic Protein 6Bone Morphogenetic Protein Receptors, Type ICalcium-Binding ProteinsHeat-Shock ProteinsHSP27 Heat-Shock ProteinsHumansHuman Umbilical Vein Endothelial CellsIntercellular Signaling Peptides and ProteinsMAP Kinase Signaling SystemMolecular ChaperonesNeovascularization, Physiologicp38 Mitogen-Activated Protein KinasesSmad1 ProteinActivin Receptors, Type IACVR1 protein, humanAdaptor Proteins, Signal TransducingBMP2 protein, humanBMP6 protein, humanBone Morphogenetic Protein 2Bone Morphogenetic Protein 6Bone Morphogenetic Protein Receptors, Type ICalcium-Binding ProteinsDLL4 protein, humanHeat-Shock ProteinsHSP27 Heat-Shock ProteinsHSPB1 protein, humanIntercellular Signaling Peptides and ProteinsKDR protein, humanMolecular Chaperonesp38 Mitogen-Activated Protein KinasesSmad1 ProteinSMAD1 protein, humanSmad5 ProteinSMAD5 protein, humanSmad5 protein, mouseVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-2VEGFA protein, humanALK2ALK3cell migrationp38 MAPKSMAD1/5

Identifiers

PMID28733457
PMCPMC5636702
OpenAlexW2738269839

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.