ReviewAmerican journal of physiology. Heart and circulatory physiology2017
Prolonged sitting leg vasculopathy: contributing factors and clinical implications.
Review in American journal of physiology. Heart and circulatory physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06592209 (Body Electric), which is not on this map. Cited by 49 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Body Electric: a Pragmatic Trial Evaluating Movement Breaks As a Public Health Strategy to Mitigate the Harms of Prolonged Sedentary Behavior
Who cites it
49 citing papers in PubMed, 4 syntheses or guidelines pooled it, 94 citations in OpenAlex.
- Effects of breaking up prolonged sitting on vascular endothelial function in adults: a systematic review.Frontiers in cardiovascular medicine · 2026Pooled it
- Acute effects of "exercise snacks" on postprandial glucose and insulin responses in populations at metabolic risk: a meta-analysis with exploratory meta-regression and vascular outcomes.Frontiers in endocrinology · 2026Pooled it
- Effect of Exercise Prior to Sedentary Behavior on Vascular Health Parameters: A Systematic Review and Meta-Analysis of Crossover Trials.Sports medicine - open · 2024Pooled it
- The Effects of Acute Exposure to Prolonged Sitting, With and Without Interruption, on Vascular Function Among Adults: A Meta-analysis.Sports medicine (Auckland, N.Z.) · 2020Pooled it
- Eight weeks of high-intensity interval training is insufficient to prevent sitting-induced endothelial dysfunction and microvascular impairment.Experimental physiology · 2026Trial
- The impact of healthy motion seating on lower-limb blood flow and blood pressure response to simulated long-haul air travel.Experimental physiology · 2026Trial
- Maintenance effects of a multilevel workplace intervention to reduce sedentary time: twenty-four-month follow-up of the group randomized clinical trial 'Stand and Move at Work'.The international journal of behavioral nutrition and physical activity · 2025Trial
- Leg fidgeting alleviates reduced oxygen extraction in the gastrocnemius muscle caused by prolonged sitting: a randomized crossover trial.European journal of applied physiology · 2025Trial
- Trial
- Trial
- Leg Fidgeting During Prolonged Sitting Improves Postprandial Glycemic Control in People with Obesity.Obesity (Silver Spring, Md.) · 2021Trial
- Efficacy of the 'Stand and Move at Work' multicomponent workplace intervention to reduce sedentary time and improve cardiometabolic risk: a group randomized clinical trial.The international journal of behavioral nutrition and physical activity · 2020Trial
- Metabolic Implications of Diet and Energy Intake during Physical Inactivity.Medicine and science in sports and exercise · 2019Trial
- Changes of blood pressure following initiation of physical inactivity and after external addition of pulses to circulation.European journal of applied physiology · 2019Trial
- No thermal skin effects at environmental 26 GHz field strengths relevant to 5G deployment.Scientific reports · 2026Article
- Acute effects of "exercise snacks" during prolonged sitting on hemodynamics and peripheral vascular function: a three-level meta-analysis.Nutrition & metabolism · 2026Article
- Acute Physiological Responses to Prolonged Sedentary Behavior: Impact on Cardiovascular Function and Muscle Activity in Young Adults.Journal of functional morphology and kinesiology · 2026Article
- Metabolic Factors Mediate the Causal Effect of Physical Activity and Sedentary Behavior on Stroke and Its Subtypes: Evidence from Mendelian Randomization Study.Molecular neurobiology · 2025Article
- Sitting knee-flexion angle does not influence endothelial-dependent vasodilation in laboratory or free-living conditions.Vascular medicine (London, England) · 2024Article
- Association of meeting the 24-h movement guidelines with high blood pressure in adolescents: a cross-sectional study.Scientific reports · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Atherosclerotic peripheral artery disease primarily manifests in the medium- to large-sized conduit arteries of the lower extremities. However, the factors underlying this increased vulnerability of leg macrovasculature to disease are largely unidentified. On the basis of recent studies, we propose that excessive time spent in the sitting position and the ensuing reduction in leg blood flow-induced shear stress cause endothelial cell dysfunction, a key predisposing factor to peripheral artery disease. In particular, this review summarizes the findings from laboratory-based sitting studies revealing acute leg vascular dysfunction with prolonged sitting in young healthy subjects, discusses the primary physiological mechanisms and the potential long-term implications of such leg vasculopathy with repeated exposure to prolonged sitting, as well as identifies strategies that may be effective at evading it.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.