ArticleAmerican journal of physiology. Heart and circulatory physiology2017
Muscle sympathetic nerve activity and volume-regulating factors in healthy pregnant and nonpregnant women.
Article in American journal of physiology. Heart and circulatory physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Muscle sympathetic nerve activity during pregnancy: A systematic review and meta-analysis.Physiological reports · 2023Pooled it
- The carotid chemoreceptor contributes to the elevated arterial stiffness and vasoconstrictor outflow in chronic obstructive pulmonary disease.The Journal of physiology · 2018Trial
- Don't go vaping my heart: e-cigarette exposure during pregnancy promotes peripartum ventricular arrhythmias and sympathetic dominance.American journal of physiology. Heart and circulatory physiology · 2025Article
- Differential regulation of sympathetic neural burst frequency and amplitude throughout normal pregnancy: a longitudinal study.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- When it's time for the sex talk, words matter.American journal of physiology. Heart and circulatory physiology · 2022Article
- Neural control of blood pressure during pregnancy in humans.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2020Review
- Sympathetic nervous system activity and reactivity in women with gestational diabetes mellitus.Physiological reports · 2020Article
- Biological variation of arginine vasopressin.European journal of applied physiology · 2020Article
- Adaptations in autonomic nervous system regulation in normal and hypertensive pregnancy.Handbook of clinical neurology · 2020Review
- The reproductive stress hypothesis.Reproduction (Cambridge, England) · 2019Review
- Sympathetic nervous system control of vascular function and blood pressure during pregnancy and preeclampsia.Journal of hypertension · 2019Review
- Adrenergic receptor blockade attenuates placental ischemia-induced hypertension.Physiological reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
Healthy, normotensive human pregnancies are associated with striking increases in both plasma volume and vascular sympathetic nerve activity (SNA). In nonpregnant humans, volume-regulatory factors including plasma osmolality, vasopressin, and the renin-angiotensin-aldosterone system have important modulatory effects on control of sympathetic outflow. We hypothesized that pregnancy would be associated with changes in the relationships between SNA (measured as muscle SNA) and volume-regulating factors, including plasma osmolality, plasma renin activity, and arginine vasopressin (AVP). We studied 46 healthy, normotensive young women (23 pregnant and 23 nonpregnant). We measured SNA, arterial pressure, plasma osmolality, plasma renin activity, AVP, and other volume-regulatory factors in resting, semirecumbent posture. Pregnant women had significantly higher resting SNA (38 ± 12 vs. 23 ± 6 bursts/min in nonpregnant women), lower osmolality, and higher plasma renin activity and aldosterone (all
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.