ArticleAmerican journal of physiology. Heart and circulatory physiology2017
Mineralocorticoid receptor antagonists attenuate exaggerated exercise pressor reflex responses in hypertensive rats.
Article in American journal of physiology. Heart and circulatory physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 12 citations in OpenAlex.
- Differential effects of eplerenone versus amlodipine on muscle metaboreflex function in hypertensive humans.Journal of clinical hypertension (Greenwich, Conn.) · 2021Trial
- Cardiac response to chronic restraint stress involves mineralocorticoid receptors in male Sprague-Dawley rats.Physiological reports · 2025Article
- Cardiovascular responses to static handgrip exercise and postexercise ischemia in heart failure with preserved ejection fraction.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Sympathetic modulation by antihypertensive drugs.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Exaggerated sympathetic and cardiovascular responses to dynamic mechanoreflex activation in rats with heart failure: Role of endoperoxide 4 and thromboxane AAutonomic neuroscience : basic & clinical · 2021Article
- No effect of endoperoxide 4 or thromboxane AExperimental physiology · 2020Article
- Investigation of the mechanisms of cyclooxygenase-mediated mechanoreflex sensitization in a rat model of simulated peripheral artery disease.American journal of physiology. Heart and circulatory physiology · 2019Article
- The renin-angiotensin system in cardiovascular autonomic control: recent developments and clinical implications.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2019Review
- Mineralocorticoids: the secret of muscle reflex dysfunction in hypertension?American journal of physiology. Heart and circulatory physiology · 2017Article
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Abstract
Exaggerated heart rate (HR) and blood pressure responses to exercise in hypertension are mediated, in part, by overactivity of the exercise pressor reflex (EPR). The mechanisms underlying this EPR dysfunction have not been fully elucidated. Previous studies have shown that stimulation of mineralocorticoid receptors (MRs) with exogenous administration of aldosterone in normal, healthy rats reproduces the EPR overactivity characteristic of hypertensive animals. Conversely, the purpose of this study was to examine whether antagonizing MR with spironolactone (SPIR) or eplerenone (EPL) in decerebrated hypertensive rats ameliorates abnormal EPR function. Changes in mean arterial pressure (MAP) and HR induced by EPR or muscle mechanoreflex (a component of EPR) activation were assessed in normotensive Wistar-Kyoto rats and spontaneously hypertensive rats (SHRs) fed normal chow (NC) or a customized diet containing either SPIR or EPL for 3 wk. SHRs treated with SPIR or EPL had significantly attenuated MAP responses to EPR (NC: 45 ± 7 mmHg, SPIR: 26 ± 4 mmHg, and EPL: 24 ± 5 mmHg,
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