ArticleBone & joint research2017
The available evidence on demineralised bone matrix in trauma and orthopaedic surgery: A systematic review.
Article in Bone & joint research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Engineering high-fidelity bone organoids: Operational classification, multilineage crosstalk, biofabrication evidence, and translational validation.Materials today. Bio · 2026Article
- Orthobiologics in spine surgery: a narrative review.Journal of spine surgery (Hong Kong) · 2025Review
- Porcine Bone Extracellular Matrix Hydrogel as a Promising Graft for Bone Regeneration.Gels (Basel, Switzerland) · 2025Article
- Bone-Regeneration Therapy Using Biodegradable Scaffolds: Calcium Phosphate Bioceramics and Biodegradable Polymers.Bioengineering (Basel, Switzerland) · 2024Review
- Demineralized Bone Matrix and Fibers in Spinal Fusion.International journal of spine surgery · 2023Article
- A Comparative Study of HA/DBM Compounds Derived from Bovine and Porcine for Bone Regeneration.Journal of functional biomaterials · 2023Article
- Current concepts of bone grafting in trauma surgery.Journal of clinical orthopaedics and trauma · 2023Article
- Biological aspects to enhance fracture healing.EFORT open reviews · 2023Review
- Combination of BMP2 and EZH2 Inhibition to Stimulate Osteogenesis in a 3D Bone Reconstruction Model.Tissue engineering. Part A · 2021Article
- Novel cell sources for bone regeneration.MedComm · 2021Review
- Article
- Demineralized Bone Matrix in Spine Surgery: A Review of Current Applications and Future Trends.International journal of spine surgery · 2021Article
- Allografts and Spinal Fusion.International journal of spine surgery · 2021Article
- Arthroscopic Contribution of Synthetic Graft in Tibiotalocalcaneal Arthroscopic Fusions.Cureus · 2020Article
- The biology and treatment of acute long-bones diaphyseal fractures: Overview of the current options for bone healing enhancement.Bone reports · 2020Review
- Boosting the Osteogenic and Angiogenic Performance of Multiscale Porous Polycaprolactone Scaffolds byACS applied materials & interfaces · 2020Article
- The Treatment of Acute Diaphyseal Long-bones Fractures with Orthobiologics and Pharmacological Interventions for Bone Healing Enhancement: A Systematic Review of Clinical Evidence.Bioengineering (Basel, Switzerland) · 2020Review
- Demineralized Bone Matrix Carriers and their Clinical Applications: An Overview.Orthopaedic surgery · 2019Review
- Augmenting endogenous repair of soft tissues with nanofibre scaffolds.Journal of the Royal Society, Interface · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this systematic literature review was to assess the clinical level of evidence of commercially available demineralised bone matrix (DBM) products for their use in trauma and orthopaedic related surgery.
methodsA total of 17 DBM products were used as search terms in two available databases: Embase and PubMed according to the Preferred Reporting Items for Systematic Reviews and Meta Analyses statement. All articles that reported the clinical use of a DBM-product in trauma and orthopaedic related surgery were included.
resultsThe literature search resulted in 823 manuscripts of which 64 manuscripts met the final inclusion criteria. The included manuscripts consisted of four randomised controlled trials (level I), eight cohort studies (level III) and 49 case-series (level IV). No clinical studies were found for ten DBM products, and most DBM products were only used in combination with other grafting materials. DBM products were most extensively investigated in spinal surgery, showing limited level I evidence that supports the use Grafton DBM (Osteotech, Eatontown, New Jersey) as a bone graft extender in posterolateral lumbar fusion surgery. DBM products are not thoroughly investigated in trauma surgery, showing mainly level IV evidence that supports the use of Allomatrix (Wright Medical, London, United Kingdom), DBX (DePuy Synthes, Zuchwil, Switzerland), Grafton DBM, or OrthoBlast (Citagenix Laval, Canada) as bone graft extenders.
conclusionsThe clinical level of evidence that supports the use of DBM in trauma and orthopaedic surgery is limited and consists mainly of poor quality and retrospective case-series. More prospective, randomised controlled trials are needed to understand the clinical effect and impact of DBM in trauma and orthopaedic surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.