Evidence map›Paper›PMID 28733211›Full record

ReviewNeuroscience2018

Synaptically Localized Transcriptional Regulators in Memory Formation.

Shusaku Uchida, Gleb P Shumyatsky

Abstract readReview
In one paragraph

Review in Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
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  7. Review
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  9. Review
  10. Experience-Regulated Neuronal Signaling in Maternal Behavior.Frontiers in molecular neuroscience · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Shusaku UchidaDivision of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan.
Gleb P ShumyatskyDepartment of Genetics, Rutgers University, 145 Bevier Rd., Piscataway, NJ 08854, USA. Electronic address: gleb@dls.rutgers.edu.
Yamaguchi University · JP

Funding

Activity-Dependent Cellular and Molecular Events Regulating MemoryR01MH107555 · NIMH · RUTGERS, THE STATE UNIV OF N.J. · PI SHUMYATSKY, GLEB P · 2016 to 2020
$1.9M
NIMH NIH HHS R01 MH107555
6 · The paper itself

Abstract

At the neuronal cell level, long-term memory formation emerges from interactions between initial activity-dependent molecular changes at the synapse and subsequent regulation of gene transcription in the nucleus. This in turn leads to strengthening of the connections back at the synapse that received the initial signal. However, the mechanisms through which this synapse-to-nucleus molecular exchange occurs remain poorly understood. Here we discuss recent studies that delineate nucleocytoplasmic transport of a special class of synaptically localized transcriptional regulators that upon receiving initial external signal by the synapse move to the nucleus to modulate gene transcription.

Indexed as

AnimalsCell NucleusGene Expression RegulationHumansMemorySynapsesTranscription, GeneticCREBCRTC1HDAC4memoryNF-κBnucleocytoplasmic shuttlingtranscription

Identifiers

PMID28733211
PMCPMC5773404
OpenAlexW2737813261

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.