Evidence map›Paper›PMID 28733090›Full record

ReviewMethods (San Diego, Calif.)2017

Intravital multiphoton microscopy as a tool for studying renal physiology and pathophysiology.

Ruben M Sandoval, Bruce A Molitoris

Abstract readReview
In one paragraph

Review in Methods (San Diego, Calif.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. The Indiana O'Brien Center for Advanced Renal Microscopic Analysis.American journal of physiology. Renal physiology · 2021
    Review
  13. Article
  14. Review
  15. Review
  16. Journal of the American Society of Nephrology : JASN · 2020
    Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ruben M SandovalIndiana University School of Medicine, Roudebush VAMC, Indiana Center for Biological Microscopy, Indianapolis, IN 46202, USA.
Bruce A MolitorisIndiana University School of Medicine, Roudebush VAMC, Indiana Center for Biological Microscopy, Indianapolis, IN 46202, USA. Electronic address: bmolitor@iu.edu.

Funding

PROBE DELIVERY COREP30DK079312 · NIDDK · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI MOLITORIS, BRUCE A · 2007 to 2021
$17.1M
Pilot--Using Zebrafish Model of Pronephros DevelopmentP50DK061594 · NIDDK · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI MOLITORIS, BRUCE A · 2002 to 2006
$5.3M
Proximal Tubule Albumin Transport in Disease States.R01DK091623 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI MOLITORIS, BRUCE A · 2011 to 2021
$4.3M
NIDDK NIH HHS P30 DK079312NIDDK NIH HHS P50 DK061594NIDDK NIH HHS R01 DK091623
6 · The paper itself

Abstract

The kidney is a complex and dynamic organ with over 40 cell types, and tremendous structural and functional diversity. Intravital multi-photon microscopy, development of fluorescent probes and innovative software, have rapidly advanced the study of intracellular and intercellular processes within the kidney. Researchers can quantify the distribution, behavior, and dynamic interactions of up to four labeled chemical probes and proteins simultaneously and repeatedly in four dimensions (time), with subcellular resolution in near real time. Thus, multi-photon microscopy has greatly extended our ability to investigate cell biology intravitally, at cellular and subcellular resolutions. Therefore, the purpose of the chapter is to demonstrate how the use in intravital multi-photon microscopy has advanced the understanding of both the physiology and pathophysiology of the kidney.

Indexed as

Acute Kidney InjuryAnimalsEndocytosisHumansIntravital MicroscopyKidneyMicroscopy, Fluorescence, MultiphotonEndocytosisGlomerular filtrationKidneyMicrovasculatureStructure-function relationship

Identifiers

PMID28733090
PMCPMC5730351

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.