ArticleRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2017
Dose-volume correlates of mandibular osteoradionecrosis in Oropharynx cancer patients receiving intensity-modulated radiotherapy: Results from a case-matched comparison.
Article in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 114 citations in OpenAlex.
- Management of Calvarial Osteoradionecrosis After Treatment of Cutaneous Malignancy: A Systematic Review.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025Pooled it
- Causal machine learning for extracting insights from observational radiotherapy data.NPJ digital medicine · 2026Article
- Dental Implants After Head and Neck Radiotherapy: From Chronological Waiting Rules to Implant-Bed-Specific Risk Stratification.Healthcare (Basel, Switzerland) · 2026Review
- Personalized Prevention of Osteoradionecrosis of the Jaws: From Clinical Risk Profiling and Site-Specific Dosimetry to Artificial Intelligence and Individualized Treatment-Effect Estimation.Journal of personalized medicine · 2026Review
- Prediction of high-dose regions in the jaw as a basis for decision-making in dental rehabilitation prior to radiotherapy in the head and neck area.Clinical and translational radiation oncology · 2026Article
- Black bone MRI morphometry for mandibular cortical bone measurement in head and neck cancer patients: prospective method comparison with CT.Oral surgery, oral medicine, oral pathology and oral radiology · 2026Article
- Clinical and dosimetric dataset of time-to-event normal tissue complication probability for osteoradionecrosis.Scientific data · 2026Article
- Radiation-specific Automated Dosimetric dental, Mandible, and maxilla Annotation for Predicting Periodontal Problems (RADMAP): A semi-automated tool for dosimetric oral risk communication and osteoradionecrosis assessment.medRxiv : the preprint server for health sciences · 2025Article
- Stiefel MD Anderson OroPharynx cancer (MDA-OPC) cohort: a single-institution, prospective longitudinal outcomes study.BMJ open · 2025Article
- Risk factors associated with prognosis in patients with osteoradionecrosis of the jaws: A single institutional experience over 15 years.Medicina oral, patologia oral y cirugia bucal · 2025Article
- Externally validated digital decision support tool for time-to-osteoradionecrosis risk-stratification using right-censored multi-institutional observational cohorts.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2025Observational
- International Expert-Based Consensus Definition, Classification Criteria, and Minimum Data Elements for Osteoradionecrosis of the Jaw: An Interdisciplinary Modified Delphi Study.International journal of radiation oncology, biology, physics · 2025Article
- Predictive modelling of mandibular osteoradionecrosis in head and neck cancer patients: clinical and dosimetric insights.Clinical oral investigations · 2025Article
- Mechanism of skull base osteoradionecrosis explored through laboratory assessment with propensity score-matched analysis.Scientific reports · 2025Article
- Identification and management of recurrent oral squamous cell carcinoma in the clinical presentation of osteoradionecrosis: a single-center case series for treatment experience sharing.BMC oral health · 2025Article
- Distinct patterns of osteoradionecrosis after photon-based radiotherapy and carbon ion radiotherapy for unresectable adenoid cystic carcinoma of the head and neck: case series from two institutions.Acta oncologica (Stockholm, Sweden) · 2025Article
- Osteoradionecrosis in osseous free flaps after maxillofacial reconstruction: a single-center experience.Frontiers in oncology · 2025Article
- A review of interaction of radiotherapy and implants in head and neck cancer - implications and strategies to improve outcomes.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2025Review
- External validation of a multimodality deep-learning normal tissue complication probability model for mandibular osteoradionecrosis trained on 3D radiation distribution maps and clinical variables.Physics and imaging in radiation oncology · 2024Article
- Mandibular dose-volume predicts time-to-osteoradionecrosis in an actuarial normal-tissue complication probability (NTCP) model: External validation of right-censored clinico-dosimetric and competing risk application across international multi-institutional observational cohorts and online graphical user interface clinical support tool assessment.medRxiv : the preprint server for health sciences · 2024Article
Corrections and comments
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Authors and funding
1 author at 4 institutions in 3 countries.
Funding
Abstract
purposeTo determine dosimetric parameters associated with osteoradionecrosis (ORN) in oropharyngeal cancer (OPC) patients in the IMRT era. MATERIAL AND
methodsSubsequent to institutional review board approval, we identified ORN in OPC patients treated with IMRT from 2002 to 2013. 1:2 case-control matching was implemented. Mandibular dose-volume histograms (DVH) were extracted. Dosimetric parameters were compared using non-parametric stats. Recursive partitioning analysis (RPA) was done to identify DVH correlates of ORN.
results68 ORN cases and 131 controls were matched. Median follow-up was 41months and median time to development of ORN was 16months. Mandibular mean dose was significantly higher in the ORN cohort (48.1 vs 43.6Gy, p<0.0001). However, the maximum dose was not statistically different. DVH bins from V35 to V73 were all significantly higher in the ORN cohort compared with controls (p<0.0006). Two DVH parameters were identified in RPA analysis, V43 and V58. The majority (81%) of ORN cases were observed with both V44≥42% and V58≥25%.
conclusionsOur data demonstrate that a wide range of DVH parameters in the intermediate and high beam path were all significantly higher in ORN patients. Mandibular V44<42% and V58<25% represent reasonable DVH constraints for IMRT plan acceptability, when tumor coverage is not compromised.
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