ReviewTrends in genetics : TIG2017
High-Throughput Imaging for the Discovery of Cellular Mechanisms of Disease.
Review in Trends in genetics : TIG, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 118 citations in OpenAlex.
- Advancing Antiviral Design: Integrating Natural Products, Computation and Targeted Delivery.Chemical biology & drug design · 2026Review
- MetaChrome: an open-source, user-friendly tool for automated metaphase chromosome analysis.Methods (San Diego, Calif.) · 2026Article
- Article
- High-Throughput Label-Free Continuous Quantification of Muscle Stem Cell Proliferation and Myogenic Differentiation.Stem cell reviews and reports · 2025Article
- MetaChrome: An Open-Source, User-Friendly Tool for Automated Metaphase Chromosome Analysis.bioRxiv : the preprint server for biology · 2025Article
- Dressed in Collagen: 2D and 3D Cardiac Fibrosis Models.International journal of molecular sciences · 2025Review
- Article
- Sexy ways: approaches to studying plant sex chromosomes.Journal of experimental botany · 2024Review
- High-throughput image processing software for the study of nuclear architecture and gene expression.Scientific reports · 2024Article
- Depth-enhanced high-throughput microscopy by compact PSF engineering.Nature communications · 2024Article
- RASP: Optimal Single Puncta Detection in Complex Cellular Backgrounds.The journal of physical chemistry. B · 2024Article
- AI-organoid integrated systems for biomedical studies and applications.Bioengineering & translational medicine · 2024Review
- hcHCR: High-Throughput Single-Cell Imaging of RNA in Human Primary Immune Cells.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Chemical genetic approaches for the discovery of bacterial cell wall inhibitors.RSC medicinal chemistry · 2023Review
- Omics and systems view of innate immune pathways.Proteomics · 2023Review
- Field-dependent deep learning enables high-throughput whole-cell 3D super-resolution imaging.Nature methods · 2023Article
- HiFENS: high-throughput FISH detection of endogenous pre-mRNA splicing isoforms.Nucleic acids research · 2022Article
- Pooled image-base screening of mitochondria with microraft isolation distinguishes pathogenic mitofusin 2 mutations.Communications biology · 2022Article
- TMPRSS2-ERG promotes the initiation of prostate cancer by suppressing oncogene-induced senescence.Cancer gene therapy · 2022Article
- High-throughput imaging of mRNA at the single-cell level in human primary immune cells.RNA (New York, N.Y.) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
High-throughput imaging (HTI) is a powerful tool in the discovery of cellular disease mechanisms. While traditional approaches to identify disease pathways often rely on knowledge of the causative genetic defect, HTI-based screens offer an unbiased discovery approach based on any morphological or functional defects of disease cells or tissues. In this review, we provide an overview of the use of HTI for the study of human disease mechanisms. We discuss key technical aspects of HTI and highlight representative examples of its practical applications for the discovery of molecular mechanisms of disease, focusing on infectious diseases and host-pathogen interactions, cancer, and rare genetic diseases. We also present some of the current challenges and possible solutions offered by novel cell culture systems and genome engineering approaches.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.