ArticleBMC genomics2017
GATE: an efficient procedure in study of pleiotropic genetic associations.
Article in BMC genomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Divided-and-combined association test for pleiotropic effects with GWAS summary statistics.BMC genomics · 2026Article
- Pleiotropic genetic association analysis with multiple phenotypes using multivariate response best-subset selection.BMC genomics · 2023Article
- A maximum kernel-based association test to detect the pleiotropic genetic effects on multiple phenotypes.Bioinformatics (Oxford, England) · 2023Article
- Summary statistics-based association test for identifying the pleiotropic effects with set of genetic variants.Bioinformatics (Oxford, England) · 2023Article
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Authors and funding
7 authors.
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Abstract
backgroundThe association studies on human complex traits are admittedly propitious to identify deleterious genetic markers. Compared to single-trait analyses, multiple-trait analyses can arguably make better use of the information on both traits and markers, and thus improve statistical power of association tests prominently. Principal component analysis (PCA) is a well-known useful tool in multivariate analysis and can be applied to this task. Generally, PCA is first performed on all traits and then a certain number of top principal components (PCs) that explain most of the trait variations are selected to construct the test statistics. However, under some situations, only utilizing these top PCs would lead to a loss of important evidences from discarded PCs and thus makes the capability compromised.
methodsTo overcome this drawback while keeping the advantages of using the top PCs, we propose a group accumulated test evidence (GATE) procedure. By dividing the PCs which is sorted in the descending order according to the corresponding eigenvalues into a few groups, GATE integrates the information of traits at the group level.
resultsSimulation studies demonstrate the superiority of the proposed approach over several existing methods in terms of statistical power. Sometimes, the increase of power can reach 25%. These methods are further illustrated using the Heterogeneous Stock Mice data which is collected from a quantitative genome-wide association study.
conclusionsOverall, GATE provides a powerful test for pleiotropic genetic associations.
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