Trial reportBMC women's health2017
Endometrial scratching in women with implantation failure after a first IVF/ICSI cycle; does it lead to a higher live birth rate? The SCRaTCH study: a randomized controlled trial (NTR 5342).
Trial report in BMC women's health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Endometrial scratch injury in infertile women undergoingThe Journal of international medical research · 2023Pooled it
- Economic evaluation of endometrial scratching before the second IVF/ICSI treatment: a cost-effectiveness analysis of a randomized controlled trial (SCRaTCH trial).Human reproduction (Oxford, England) · 2022Trial
- Endometrial scratching in women with one failed IVF/ICSI cycle-outcomes of a randomised controlled trial (SCRaTCH).Human reproduction (Oxford, England) · 2021Trial
- Enrichment of cell cycle pathways in progesterone-treated endometrial organoids of infertile women compared to fertile women.Journal of assisted reproduction and genetics · 2024Article
- The endometrial transcriptome of infertile women with and without implantation failure.Acta obstetricia et gynecologica Scandinavica · 2024Article
- Endometrial scratching and intralipid treatment-no general recommendations.Frontiers in reproductive health · 2024Article
- Local production of 17β-oestradiol in the endometrium during the implantation window: a pilot study.Reproduction & fertility · 2023Article
- Assisted reproductive technology and interactions between serum basal FSH/LH and ovarian sensitivity index.Frontiers in endocrinology · 2023Article
- Endometrial delay is found to be part of a normal individual dynamic transformation process.Archives of gynecology and obstetrics · 2021Article
- Medical or surgical treatment before embryo transfer improves outcomes in women with abnormal endometrial BCL6 expression.Journal of assisted reproduction and genetics · 2019Article
- Endometrial scratching prior to IVF; does it help and for whom? A systematic review and meta-analysis.Human reproduction open · 2019Review
- Does endometrial scratching increase the rate of spontaneous conception in couples with unexplained infertility and a good prognosis (Hunault > 30%)? Study protocol of the SCRaTCH-OFO trial: a randomized controlled trial.BMC pregnancy and childbirth · 2018Article
- Article
- Endometrial receptivity enhancement through induced injury and repair during ovarian stimulation: the Receptivity Enhancement by Follicular-phase Renewal after Endometrial ScratcHing (REFRESH) trial protocol.Human reproduction open · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
41 authors at 20 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSuccess rates of assisted reproductive techniques (ART) are approximately 30%, with the most important limiting factor being embryo implantation. Mechanical endometrial injury, also called 'scratching', has been proposed to positively affect the chance of implantation after embryo transfer, but the currently available evidence is not yet conclusive. The primary aim of this study is to determine the effect of endometrial scratching prior to a second fresh in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycle on live birth rates in women with a failed first IVF/ICSI cycle.
methodMulticenter randomized controlled trial in Dutch academic and non-academic hospitals. A total of 900 women will be included of whom half will undergo an endometrial scratch in the luteal phase of the cycle prior to controlled ovarian hyperstimulation using an endometrial biopsy catheter. The primary endpoint is the live birth rate after the 2 DISCUSSION: Multiple studies have been performed to investigate the effect of endometrial scratching on live birth rates in women undergoing IVF/ICSI cycles. Due to heterogeneity in both the method and population being scratched, it remains unclear which group of women will benefit from the procedure. The SCRaTCH trial proposed here aims to investigate the effect of endometrial scratching prior to controlled ovarian hyperstimulation in a large group of women undergoing a second IVF/ICSI cycle.
trial registrationNTR 5342 , registered July 31 PROTOCOL VERSION: Version 4.10, January 4th, 2017.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.