Trial reportArthritis research & therapy2017
Ultrasonography and dual-energy computed tomography provide different quantification of urate burden in gout: results from a cross-sectional study.
Trial report in Arthritis research & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 59 citations in OpenAlex.
- Advanced imaging techniques in crystal arthritis.Therapeutic advances in musculoskeletal disease · 2025Review
- Associations of Changes in Knee Hyaline Cartilage Composition Measured With Dual-Energy Computed Tomography in Gout, Aging and Osteoarthritis.Cartilage · 2024Article
- Correlations of characteristics with tissue involvement in knee gouty arthritis: Magnetic resonance imaging analysis.Heliyon · 2024Article
- Factors influencing the kinetics of MSU crystal depletion measured with dual-energy CT in patients with gout.RMD open · 2023Article
- Burden and distribution of monosodium urate deposition in patients with hyperuricemia and gout: a cross-sectional Chinese population-based dual-energy CT study.Quantitative imaging in medicine and surgery · 2023Article
- Optimization of dual energy computed tomography post-processing to reduce lower limb artifacts in gout.Quantitative imaging in medicine and surgery · 2022Article
- Entheseal involvement of the lower extremities in gout: an ultrasonographic descriptive observational study.Clinical rheumatology · 2021Observational
- Limitations of dual-energy CT in the detection of monosodium urate deposition in dense liquid tophi and calcified tophi.Skeletal radiology · 2021Article
- Sonographic estimation of monosodium urate burden predicts the fulfillment of the 2016 remission criteria for gout: a 12-month study.Arthritis research & therapy · 2021Observational
- External validation of Gout-calculator performance on a cohort of acute arthritis (SYNOLACTATE) sparing distal joints such as hallux and midfoot. A cross-sectional study of 170 patients.Clinical rheumatology · 2021Article
- Ultrasonography and dual-energy computed tomography: impact for the detection of gouty deposits.Ultrasonography (Seoul, Korea) · 2021Article
- The Role of Advanced Imaging in Gout Management.Frontiers in immunology · 2021Review
- Association of Specific Comorbidities with Monosodium Urate Crystal Deposition in Urate-Lowering Therapy-Naive Gout Patients: A Cross-Sectional Dual-Energy Computed Tomography Study.Journal of clinical medicine · 2020Article
- Utility of Ultrasound and Dual Energy CT in Crystal Disease Diagnosis and Management.Current rheumatology reports · 2020Review
- Dual-energy computed-tomography-based discrimination between basic calcium phosphate and calcium pyrophosphate crystal depositionTherapeutic advances in musculoskeletal disease · 2020Article
- The application of dual-energy computed tomography in the diagnosis of musculoskeletal disorders: a review of current concepts and applications.La Radiologia medica · 2019Review
- Concurrent validity of provisional remission criteria for gout: a dual-energy CT study.Arthritis research & therapy · 2019Article
- Gout: Update on Dual-Energy Computed Tomography with Emphasis on Artifact Identification.Current rheumatology reports · 2018Review
- Article
- Monosodium urate burden assessed with dual-energy computed tomography predicts the risk of flares in gout: a 12-month observational study : MSU burden and risk of gout flare.Arthritis research & therapy · 2018Observational
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUltrasonography (US) and dual-energy computed tomography (DECT) can assess urate burden in gout. The objective of this study was to compare the quantification of urate deposition provided by US to the one provided by DECT.
methodsPatients with a diagnosis of gout were prospectively recruited to undergo quantification of urate deposition using US and DECT. US examination for tophi and the double contour (DC) sign was performed on the knees and feet and corresponding DECT scans provided volumes of tophi and of overall urate deposition. The primary endpoint was the intra-class correlation coefficient (ICC) of the volume of the index tophus measured by US and DECT and its 95% confidence interval (CI 95%).
resultsOf the 64 patients included, 34 presented with at least one tophus on US. DECT inter-reader agreement for urate deposition was perfect with an ICC of 1 (1-1) and good for the measurement of the index tophus with an ICC of 0.69 (0.47-0.83). The ICC for the measurement of the index tophus between the two techniques was poor with a value of 0.45 (0.1-0.71). The average ratio between the index tophi volume as assessed by DECT and US was 0.65. The number of DC-positive joints did not correlate with DECT volume of overall deposits (Spearman correlation coefficient of 0.23).
conclusionsDECT measurements of tophi give smaller volumes to the same tophi measured with US, and US signs of urate deposition in joints do not correlate with overall DECT volumes of extra-articular deposition.
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