ArticleParasites & vectors2017
The excretory-secretory products of Echinococcus granulosus protoscoleces directly regulate the differentiation of B10, B17 and Th17 cells.
Article in Parasites & vectors, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 56 citations in OpenAlex.
- The TPx Protein ofCells · 2026Article
- Molecular characterization and functional effect on canie peripheral blood mononuclear cells of phosphoglycerate kinase from Echinococcus granulosus.Parasitology research · 2026Article
- First analysis of Spirometra mansoni excretory-secretory proteins by the 4D-DIA method.Parasite (Paris, France) · 2026Article
- Regulatory B cells in parasitic infections: roles and therapeutic potential.Parasitology research · 2025Review
- Multi-omics approaches reveal the mechanisms underlying the interaction between cyst fluid ofFrontiers in immunology · 2025Article
- Immunomodulatory effects of hydatid antigens on mesenchymal stem cells: gene expression alterations and functional consequences.Frontiers in microbiology · 2024Article
- Hydatid fluid fromFrontiers in cellular and infection microbiology · 2024Article
- Characterization of protein cargo of Echinococcus granulosus extracellular vesicles in drug response and its influence on immune response.Parasites & vectors · 2023Article
- Article
- Autoimmunity in Human CE: Correlative with The Fertility Status of The CE Cyst.Helminthologia · 2022Article
- Helminth and Host Crosstalk: New Insight Into Treatment of Obesity and Its Associated Metabolic Syndromes.Frontiers in immunology · 2022Review
- Proteomic Analysis of Plasma-Derived Extracellular Vesicles From Mice WithFrontiers in cellular and infection microbiology · 2022Article
- Transcriptomic Profiles of Splenic CD19Frontiers in veterinary science · 2022Article
- IL-10 regulates Th17 response to inhibit hepatobiliary injury caused byFrontiers in cellular and infection microbiology · 2022Article
- The non-oral infection of larvalFrontiers in immunology · 2022Article
- The best protection is early detection: Fostering timely and accurate screening.Biomedical journal · 2021Article
- Evidence of Immune Modulators in the Secretome of the Equine TapewormPathogens (Basel, Switzerland) · 2021Article
- Ex vivo characterization of Breg cells in patients with chronic Chagas disease.Scientific reports · 2021Article
- Metabolomics Analysis of Splenic CD19Frontiers in veterinary science · 2021Article
- Immunometabolism: Towards a Better Understanding the Mechanism of Parasitic Infection and Immunity.Frontiers in immunology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExcretory-secretory products (ESPs) released by helminths are well-known to regulate T cell responses in the host. However, their direct influence in the differentiation of naïve T cells, and especially B cells, remains largely unknown. This study investigated the effects of Echinococcus granulosus protoscoleces ESPs (EgPSC-ESPs) on the differentiation of IL-10-producing B cells (B10), IL-17A-producing B cells (B17) and Th17 cells.
methodsBALB/c mice injected with EgPSC were used to evaluate the in vivo profiles of B10, B17 and Th17 cells. In vitro purified CD19
resultsIn contrast to the control group, infected mice showed higher frequencies of B10, B17 and Th17 cells, and higher levels of IL-10 and IL-17A in the sera. Interestingly, B17 cells were first identified to express CD19
conclusionsOur findings indicate that ESPs released by EgPSC can directly regulate the differentiation of B10, B17 and Th17 cells, which appear to be heat-labile and carbohydrate-dependent.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.