ArticleBreast cancer research : BCR2017
Body size in early life and risk of breast cancer.
Article in Breast cancer research : BCR, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Dose response relationship between breast cancer and somatotypes during childhood: a systematic review and meta-analysis.British journal of cancer · 2023Pooled it
- Anthropometry and the Risk of Breast Cancer in Moroccan Women: A Large Multicentric Case-Control Study.Current oncology (Toronto, Ont.) · 2025Article
- Disentangling the aetiological pathways between body mass index and site-specific cancer risk using tissue-partitioned Mendelian randomisation.British journal of cancer · 2023Article
- Childhood adiposity, serum metabolites and breast density in young women.Breast cancer research : BCR · 2022Article
- Birthweight, childhood body size, and timing of puberty and risks of breast cancer by menopausal status and tumor receptor subtypes.Breast cancer research : BCR · 2022Article
- Early-Life Body Adiposity and the Breast Tumor Transcriptome.Journal of the National Cancer Institute · 2021Article
- Dairy consumption during adolescence and endometriosis risk.American journal of obstetrics and gynecology · 2020Article
- Is obesity in childhood protective for breast cancer in young women?Translational cancer research · 2019Article
- Age-specific breast cancer risk by body mass index and familial risk: prospective family study cohort (ProF-SC).Breast cancer research : BCR · 2018Article
- Childhood body size and midlife mammographic breast density in foreign-born and U.S.-born women in New York City.Annals of epidemiology · 2018Article
- Associations between childhood body size and seventeen adverse outcomes: analysis of 65,057 European women.Scientific reports · 2017Article
- Consistency, now what?Breast cancer research : BCR · 2017Article
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Abstract
backgroundBody size in early life is inversely associated with adult breast cancer (BC) risk, but it is unclear whether the associations differ by tumor characteristics.
methodsIn a pooled analysis of two Swedish population-based studies consisting of 6731 invasive BC cases and 28,705 age-matched cancer-free controls, we examined the associations between body size in early life and BC risk. Self-reported body sizes at ages 7 and 18 years were collected by a validated nine-level pictogram (aggregated into three categories: small, medium and large). Odds ratios (OR) and corresponding 95% confidence intervals (CI) were estimated from multivariable logistic regression models in case-control analyses, adjusting for study, age at diagnosis, age at menarche, number of children, hormone replacement therapy, and family history of BC. Body size change between ages 7 and 18 were also examined in relation to BC risk. Case-only analyses were performed to test whether the associations differed by tumor characteristics.
resultsMedium or large body size at age 7 and 18 was associated with a statistically significant decreased BC risk compared to small body size (pooled OR (95% CI): comparing large to small, 0.78 (0.70-0.86), P
conclusionsOur data provide further support for a strong and independent inverse relationship between early life body size and BC risk. The association between body size at age 18 and tumor size could be mediated by mammographic density.
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