ArticleJournal of dental research2017
IRF6 and SPRY4 Signaling Interact in Periderm Development.
Article in Journal of dental research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- A Novel Nonsense Variant in TBX15 Transcription Factor Suggests an Expanded Genetic Spectrum Of Submucous Cleft Palate.International dental journal · 2026Article
- Article
- Neural crest and periderm-specific requirements of Irf6 during neural tube and craniofacial development.Developmental biology · 2025Review
- A Single-cell Atlas of Developing Mouse Palates Reveals Cellular and Molecular Transitions in Periderm Cell Fate.Genomics, proteomics & bioinformatics · 2025Article
- Combining genetic and single-cell expression data reveals cell types and novel candidate genes for orofacial clefting.Scientific reports · 2024Article
- Single-cell transcriptome and chromatin accessibility mapping of upper lip and primary palate fusion.Journal of cellular and molecular medicine · 2024Article
- Neural crest and periderm-specific requirements ofbioRxiv : the preprint server for biology · 2024Article
- Sprouty4 is epigenetically upregulated in human colorectal cancer.Epigenetics · 2023Article
- Sprouty 4 expression in human oral squamous cell carcinogenesis.Journal of dental sciences · 2023Article
- Analysis of candidate genes for cleft lip ± cleft palate using murine single-cell expression data.Frontiers in cell and developmental biology · 2023Article
- The Mafb cleft-associated variant H131Q is not required for palatogenesis in the mouse.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Article
- Article
- SPECC1L regulates palate development downstream of IRF6.Human molecular genetics · 2020Article
- Downregulation of FGF Signaling byJBMR plus · 2019Article
- The molecular anatomy of mammalian upper lip and primary palate fusion at single cell resolution.Development (Cambridge, England) · 2019Article
- Wnt signaling in orofacial clefts: crosstalk, pathogenesis and models.Disease models & mechanisms · 2019Review
- Gene-Gene Interactions among SPRYs for Nonsyndromic Cleft Lip/Palate.Journal of dental research · 2019Article
- IRF6 and AP2A Interaction Regulates Epidermal Development.The Journal of investigative dermatology · 2018Article
- ARHGAP29 Mutation Is Associated with Abnormal Oral Epithelial Adhesions.Journal of dental research · 2017Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Rare mutations in IRF6 and GRHL3 cause Van der Woude syndrome, an autosomal dominant orofacial clefting disorder. Common variants in IRF6 and GRHL3 also contribute risk for isolated orofacial clefting. Similarly, variants within genes that encode receptor tyrosine kinase (RTK) signaling components, including members of the FGF pathway, EPHA3 and SPRY2, also contribute risk for isolated orofacial clefting. In the mouse, loss of Irf6 or perturbation of Fgf signaling leads to abnormal oral epithelial adhesions and cleft palate. Oral adhesions can result from a disruption of periderm formation. Here, we find that IRF6 and SPRY4 signaling interact in periderm function. We crossed Irf6 heterozygous ( Irf6
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.